Rabbit polyclonal MMP25 antibody (A3032)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MMP25 antibody (A3032)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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MMP20 antibody, MMPL1 antibody, MMP-25 antibody, MMP20A antibody, MT6MMP antibody, MTMMP6 antibody, MT-MMP6 antibody, MT6-MMP antibody, MT-MMP 6 antibody
Leukolysin antibody|Matrix metalloproteinase 20 antibody|Matrix metalloproteinase 25 antibody|Matrix metalloproteinase 25 preproprotein antibody|Matrix metalloproteinase like 1 antibody|Membrane type 6 matrix metalloproteinase antibody|Membrane type matrix metalloproteinase 6 antibody|MMP 25 antibody|MMP20 antibody|MMP20A antibody|MMP25 antibody|MMPL1 antibody|MT MMP 6 antibody|MT MMP6 antibody|MT6 MMP antibody|MT6MMP antibody|MTMMP6 antibody|Anti-MMP20L antibody (ab180571)

SCBT cat No: sc-101453|

Name

Rabbit polyclonal MMP25 antibody

Catalogue No.

A3032

Reactivity

Human, Mouse

Immunogen

A synthetic peptide of human MMP25

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 63kDa/Observed: Refer to Figures

Formulation

MMP25 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MMP25 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MMP20 antibody, MMPL1 antibody, MMP-25 antibody, MMP20A antibody, MT6MMP antibody, MTMMP6 antibody, MT-MMP6 antibody, MT6-MMP antibody, MT-MMP 6 antibody

Database links

Human UniProt/Swiss-Prot:Q9NPA2

Protein names

MMP20, MMPL1, MMP-25, MMP20A, MT6MMP, MTMMP6, MT-MMP6, MT6-MMP, MT-MMP 6

Protein function

May activate progelatinase A.

Protein tissue specificity

Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas.

Protein sequence and domain

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.Belongs to the peptidase M10A family.; Contains 4 hemopexin repeats.

Protein post-translational modifications

The precursor is cleaved by a furin endopeptidase.

Protein cellular localization

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.

Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.

Note

AntibodyPlus can customize MMP25 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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