Rabbit polyclonal MPP1 antibody (A6298)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MPP1 antibody (A6298)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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MRG1 antibody, PEMP antibody, AAG12 antibody, EMP55 antibody, DXS552E antibody
55 kDa erythrocyte membrane protein antibody|MPP 1 antibody|MPP1 antibody|MRG 1 antibody|MRG1 antibody|OTTHUMP00000026054 antibody|OTTHUMP00000196176 antibody|p55 antibody|palmitoylated 1 antibody|Palmitoylated erythrocyte membrane protein antibody|Palmitoylated membrane protein 1 antibody|PEMP antibody|Anti-MPP1 antibody (ab96255)

SCBT cat No: sc-13603|

Name

Rabbit polyclonal MPP1 antibody

Catalogue No.

A6298

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human MPP1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 52kDa/Observed: Refer to Figures

Formulation

MPP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MPP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MRG1 antibody, PEMP antibody, AAG12 antibody, EMP55 antibody, DXS552E antibody

Database links

Human UniProt/Swiss-Prot:Q00013

Protein names

MRG1, PEMP, AAG12, EMP55, DXS552E

Protein function

Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

Belongs to the MAGUK family.; Contains 1 guanylate kinase-like domain.; Contains 1 PDZ (DHR) domain.; Contains 1 SH3 domain.

Protein post-translational modifications

Extensively palmitoylated by ZDHHC17, palmitoylation is essential for membrane organization and is crucial for proper erythrocytes morphology.

Protein cellular localization

Membrane; Lipid-anchor. Cell projection, stereocilium . Note: Colocalizes with WHRN at stereocilium tip during hair cell development (By similarity). Colocalizes with MPP5 in the retina, at the outer limiting membrane (OLM). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC). Colocalizes with NF2 in non-myelin-forming Schwann cells.

Background

This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.

Note

AntibodyPlus can customize MPP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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