Rabbit Polyclonal MRE11 antibody (STJ94194)

$99.00$319.00

Reactivity: Human, Mouse, Rat, Monkey
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal MRE11 antibody (STJ94194)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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MRE11A antibody, HNGS1 antibody, MRE11 antibody,|AT like disease antibody|Ataxia telangiectasia disorder like antibody|ATLD antibody|DNA recombination and repair protein antibody|Double strand break repair protein MRE11A antibody|Double-strand break repair protein MRE11A antibody|endo/exonuclease Mre11 antibody|HNGS1 antibody|meiotic recombination (S. cerevisiae) 11 homolog A antibody|Meiotic recombination 11 homolog 1 antibody|meiotic recombination 11 homolog A (S. cerevisiae) antibody|Meiotic recombination 11 homolog A antibody|MmMRE11A antibody|Mre 11 antibody|MRE 11a antibody|MRE 11b antibody|MRE11 homolog 1 antibody|MRE11 homolog A antibody|MRE11 meiotic recombination 11 homolog A (S. cerevisiae) antibody|MRE11 meiotic recombination 11 homolog A antibody|MRE11_HUMAN antibody|MRE11A antibody|MRE11b antibody|OTTHUMP00000236830 antibody|OTTHUMP00000236831 antibody|OTTHUMP00000236832 antibody|OTTHUMP00000236833 antibody|Anti-Mre11 antibody [12D7] (ab214)
SCBT cat No: sc-135992|sc-5859|sc-22767|

 

Name

MRE11 Polyclonal Antibody

Catalogue No.

STJ94194

Reactivity

Human, Mouse, Rat, Monkey

Specificity

MRE11 Polyclonal Antibody detects endogenous levels of MRE11 protein.

Immunogen

Synthesized peptide derived from MRE11 at AA range 200-280

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

80 kDa

Formulation

MRE11 Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

MRE11 Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Double-strand break repair protein MRE11A antibody, Meiotic recombination 11 homolog 1 antibody, MRE11 homolog 1 antibody, Meiotic recombination 11 homolog A antibody, MRE11 homolog A antibody

Database links

Human UniProt/Swiss-Prot:P49959;Mouse UniPort/Swiss-Prot: Q61216;Rat UniProt/Swiss-Port: Q9JIM0;Human Entrez Gene: 4361;Mouse Entrez Gene: 17535;Rat Entrez Gene: Rn.209040

Protein names

Double-strand break repair protein MRE11A , Meiotic recombination 11 homolog 1 , MRE11 homolog 1 , Meiotic recombination 11 homolog A , MRE11 homolog A

Protein function

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3′-5′ exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point . The complex may also be required for DNA damage signaling via activation of the ATM kinase . In telomeres the MRN complex may modulate t-loop formation . / Mn2+

Involvement in disease

Ataxia-telangiectasia-like disorder 1 (ATLD1) [MIM:604391]: A rare disorder characterized by progressive cerebellar ataxia, dysarthria, abnormal eye movements, and absence of telangiectasia. ATLD patients show normal levels of total IgG, IgA and IgM, although there may be reduced levels of specific functional antibodies. At the cellular level, ATLD exhibits hypersensitivity to ionizing radiation and radioresistant DNA synthesis. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Note: Defects in MRE11A can be a cause of nephronophthisis-related ciliopathies (NPHP-RC), a group of recessive diseases that affect kidney, retina and brain. A homozygous truncating mutation MRE11A has been found in patients with cerebellar vermis hypoplasia, ataxia and dysarthria. .

Protein sequence and domain

Belongs to the MRE11/RAD32 family.

Protein cellular localization

Nucleus / Chromosome > telomere

Research area

All research areas>Tumor Suppressor/Apoptosis>MRE11
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize MRE11 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


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Antibody customer reviews & validation data - 105

Validation data ID: 105

Submission date: 2017-02-08

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Result figure:
Result figure

Figure description:

The figure shows the image of the membrane that was blotted for MRE11. 4 cell lines are shown in this blot. Breast cancer cell lines MCF7, MDA-MB-231, DCIS and lung cancer cell line A549. The band was very specific and could be detected at even 5 seconds exposure. The specific treatments are left out because of confidentiality of the project.

Product name

Anti-MRE11 antibody (Rabbit Polyclonal)

Product catalog No.

STJ94194

Product type

Primary antibody

Supplier

St John's Laboratory Ltd

Application type

Western Blot

Antibody specificity rating

Excellent

Antibody overall rating

Excellent

Your comments

I could detect bands using 5 different cell lines with 1:2000 dilution. I could detect the bands as early as 5 seconds exposure.

Detailed protocol

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