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Rabbit polyclonal MSH3 antibody (A5681)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal MSH3 antibody.
Check alternative names for the antibodyExpand
DUP antibody, MRP1 antibody
Divergent upstream protein antibody|DNA mismatch repair protein antibody|DNA mismatch repair protein Msh 3 antibody|DNA mismatch repair protein MSH3 antibody|DUC 1 antibody|DUC1 antibody|DUG antibody|DUP antibody|hMSH3 antibody|MGC163306 antibody|MGC163308 antibody|Mismatch repair protein 1 antibody|MRP 1 antibody|MRP1 antibody|MSH 3 antibody|MSH3 antibody|MSH3_HUMAN antibody|MutS homolog 3 (E. coli) antibody|MutS homolog 3 antibody|Anti-MSH3 antibody [EPR4334(2)] (ab111107)
SCBT cat No: sc-271080|sc-271079|sc-11441|sc-5686|
Rabbit polyclonal MSH3 antibody
|Catalogue No.|| |
Recombinant protein of human MSH3
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 127kDa/Observed: Refer to Figures
MSH3 antibody was tube-contained.
MSH3 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
DUP antibody, MRP1 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
|Protein sequence and domain|| |
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer.
AntibodyPlus can customize MSH3 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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