Rabbit polyclonal MSH3 antibody (A5681)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MSH3 antibody (A5681)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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DUP antibody, MRP1 antibody
Divergent upstream protein antibody|DNA mismatch repair protein antibody|DNA mismatch repair protein Msh 3 antibody|DNA mismatch repair protein MSH3 antibody|DUC 1 antibody|DUC1 antibody|DUG antibody|DUP antibody|hMSH3 antibody|MGC163306 antibody|MGC163308 antibody|Mismatch repair protein 1 antibody|MRP 1 antibody|MRP1 antibody|MSH 3 antibody|MSH3 antibody|MSH3_HUMAN antibody|MutS homolog 3 (E. coli) antibody|MutS homolog 3 antibody|Anti-MSH3 antibody [EPR4334(2)] (ab111107)

SCBT cat No: sc-271080|sc-271079|sc-11441|sc-5686|

Name

Rabbit polyclonal MSH3 antibody

Catalogue No.

A5681

Reactivity

Human

Immunogen

Recombinant protein of human MSH3

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 127kDa/Observed: Refer to Figures

Formulation

MSH3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MSH3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DUP antibody, MRP1 antibody

Database links

Human UniProt/Swiss-Prot:P20585

Protein names

DUP, MRP1

Protein function

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Protein sequence and domain

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

Background

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer.

Research area

All research areas>Tumor Suppressor/Apoptosis>MSH
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize MSH3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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