Rabbit polyclonal MTAP antibody (A1049)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MTAP antibody (A1049)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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MTAP antibody,MSAP antibody,c86fus antibody
5′ methylthioadenosine phosphorylase antibody|5”-methylthioadenosine phosphorylase antibody|BDMF antibody|c86fus antibody|DMSFH antibody|DMSMFH antibody|Epididymis luminal protein 249 antibody|HEL 249 antibody|LGMBF antibody|MeSAdo phosphorylase antibody|Methylthioadenosine phosphorylase antibody|MSAP antibody|MTA phosphorylase antibody|MTAP antibody|MTAP_HUMAN antibody|MTAPase antibody|S methyl 5 thioadenosine phosphorylase antibody|S methyl 5′ thioadenosine phosphorylase antibody|S-methyl-5”-thioadenosine phosphorylase antibody|Anti-MTAP antibody [EPR6893] (ab126770)

SCBT cat No: sc-100782|sc-17017|sc-17015|

Name

Rabbit polyclonal MTAP antibody

Catalogue No.

A1049

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MTAP

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 31kDa/Observed: Refer to Figures

Formulation

MTAP antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MTAP antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MTAP antibody,MSAP antibody,c86fus antibody

Database links

Human UniProt/Swiss-Prot:Q13126

Protein names

MTAP,MSAP,c86fus

Protein function

Catalyzes the reversible phosphorylation of S-methyl-5′-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.

Protein tissue specificity

Ubiquitously expressed.

Protein sequence and domain

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Protein cellular localization

Cytoplasm. Nucleus .

Background

MTAP is an enzyme that is essential for the salvage pathway for both adenine and methionine synthesis. MTAP catalyzes the cleavage of 5’-methylthioadenosine into adenine and 5-methylthio-D-ribose-1-phosphate. Adenine is then used to generate AMP whereas 5-methylthio-D-ribose-1-phosphate is converted into methionine (1,2). MTAP is expressed in all normal cells and tissues, although frequently lost in different human tumors including pancreatic adenocarcinoma, neuroendocrine tumors, non-small cell lung carcinoma and breast carcinoma. MTAP is usually codeleted with p16 (cdkN2a/ARF) (3-5). MTAP overexpression in breast cancer cells inhibits their ability to form colonies in soft agar, thereby implicating its function as a tumor suppressor (6).

Note

AntibodyPlus can customize MTAP antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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