Rabbit polyclonal MTHFD1L antibody (A7969)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MTHFD1L antibody (A7969)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MTHFD1L antibody.

Alternative names:

Check alternative names for the antibody

Expand

FTHFSDC1 antibody, MTC1THFS antibody, dJ292B18.2 antibody
10-formyl-THF synthetase antibody|C1TM_HUMAN antibody|Formyltetrahydrofolate synthetase antibody|formyltetrahydrofolate synthetase domain containing 1 antibody|FTHFSDC1 antibody|methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like antibody|mitochondrial antibody|Monofunctional C1-tetrahydrofolate synthase antibody|MTC1THFS antibody|MTHFD1L antibody|RP1-292B18.2 antibody|Anti-MTHFD1L antibody (ab189981)

SCBT cat No: sc-100783|sc-367843|

Name

Rabbit polyclonal MTHFD1L antibody

Catalogue No.

A7969

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MTHFD1L

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 106kDa/Observed: Refer to figures

Formulation

MTHFD1L antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MTHFD1L antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FTHFSDC1 antibody, MTC1THFS antibody, dJ292B18.2 antibody

Database links

Human UniProt/Swiss-Prot:Q6UB35

Protein names

FTHFSDC1, MTC1THFS, dJ292B18.2

Protein function

May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2.

Protein tissue specificity

Detected in most tissues, highest expression found in placenta, thymus and brain. Low expression is found in liver and skeletal muscle. Up-regulated in colon adenocarcinoma.

Protein sequence and domain

This monofunctional enzyme consists of two major domains: an N-terminal inactive methylene-THF dehydrogenase and cyclohydrolase domain and an active larger formyl-THF synthetase C-terminal domain.In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.; In the C-terminal section; belongs to the formate–tetrahydrofolate ligase family.

Protein cellular localization

Mitochondrion .

Background

The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.

Note

AntibodyPlus can customize MTHFD1L antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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