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Rabbit polyclonal MVP antibody (A1980)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal MVP antibody.
Check alternative names for the antibodyExpand
LRP antibody, VAULT1 antibody
LRP antibody|Major vault protein antibody|Major vault protein, rat, homolog of antibody|MVP antibody|MVP_HUMAN antibody|testicular secretory protein Li 30 antibody|VAULT 1 antibody|VAULT1 antibody|Anti-MVP antibody [EPR13227(B)] (ab175239)
SCBT cat No: sc-23916|sc-23917|sc-135975|sc-390134|sc-390141|sc-18701|sc-366042|sc-18700|
Rabbit polyclonal MVP antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human MVP
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 99kDa/Observed: Refer to Figures
MVP antibody was tube-contained.
MVP antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
LRP antibody, VAULT1 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
|Protein tissue specificity|| |
Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
|Protein sequence and domain|| |
MVP 3 mediates interaction with PTEN.; MVP 4 mediates interaction with PARP4.Contains 9 MVP (vault) repeats.
|Protein post-translational modifications|| |
Phosphorylated on Tyr residues after EGF stimulation.; Dephosphorylated by PTPN11.
|Protein cellular localization|| |
Cytoplasm . Nucleus, nuclear pore complex . Cytoplasm, perinuclear region . Note: 5% found in the nuclear pore complex . Translocates from the nucleus to the cytoplasm upon EGF treatment .
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
AntibodyPlus can customize MVP antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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