Rabbit polyclonal MVP antibody (A1980)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MVP antibody (A1980)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

LRP antibody, VAULT1 antibody
LRP antibody|Major vault protein antibody|Major vault protein, rat, homolog of antibody|MVP antibody|MVP_HUMAN antibody|testicular secretory protein Li 30 antibody|VAULT 1 antibody|VAULT1 antibody|Anti-MVP antibody [EPR13227(B)] (ab175239)

SCBT cat No: sc-23916|sc-23917|sc-135975|sc-390134|sc-390141|sc-18701|sc-366042|sc-18700|

Name

Rabbit polyclonal MVP antibody

Catalogue No.

A1980

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MVP

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 99kDa/Observed: Refer to Figures

Formulation

MVP antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MVP antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LRP antibody, VAULT1 antibody

Database links

Human UniProt/Swiss-Prot:Q14764

Protein names

LRP, VAULT1

Protein function

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Protein tissue specificity

Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.

Protein sequence and domain

MVP 3 mediates interaction with PTEN.; MVP 4 mediates interaction with PARP4.Contains 9 MVP (vault) repeats.

Protein post-translational modifications

Phosphorylated on Tyr residues after EGF stimulation.; Dephosphorylated by PTPN11.

Protein cellular localization

Cytoplasm . Nucleus, nuclear pore complex . Cytoplasm, perinuclear region . Note: 5% found in the nuclear pore complex . Translocates from the nucleus to the cytoplasm upon EGF treatment .

Background

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.

Note

AntibodyPlus can customize MVP antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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