Rabbit polyclonal MYCN antibody (A0499)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MYCN antibody (A0499)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

NMYC antibody, ODED antibody, MODED antibody, N-myc antibody, MYCNOT antibody, bHLHe37 antibody
bHLHe37 antibody||Anti-n-Myc antibody [NCM II 100] – ChIP Grade (ab16898)

SCBT cat No: sc-22836|

Name

Rabbit polyclonal MYCN antibody

Catalogue No.

A0499

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MYCN

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 65kDa/Observed: Refer to Figures

Formulation

MYCN antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MYCN antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NMYC antibody, ODED antibody, MODED antibody, N-myc antibody, MYCNOT antibody, bHLHe37 antibody

Database links

Human UniProt/Swiss-Prot:P04198

Protein names

NMYC, ODED, MODED, N-myc, MYCNOT, bHLHe37

Protein function

Positively regulates the transcription of NCYM in neuroblastoma cells .

Protein tissue specificity

Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).

Protein sequence and domain

Contains 1 bHLH (basic helix-loop-helix) domain.

Protein post-translational modifications

Phosphorylated by GSK3-beta which may promote its degradation.

Protein cellular localization

Nucleus.

Background

MYCN, also named as BHLHE37 and NMYC, is a transcription factor. It is primarily expressed in normal developing embryos and is thought to be critical in brain and other neural development. It is often amplified in human neuroblastomas. IR34A can suppress MYCN expression, it suggest MYCN has a role in cell growth. The expression of the MCYN is upregulated in a variety of human tumors, most requently neuroblastoma, where the level of expression appearts to increase as teh tumor progress.

Research area

All research areas>Transcription Regulators>Myc
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize MYCN antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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