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Rabbit polyclonal MyD88 antibody (A0980)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
Mutant myeloid differentiation primary response 88 antibody|MYD 88 antibody|Myd88 antibody|MYD88_HUMAN antibody|MYD88D antibody|Myeloid differentiation marker 88 antibody|Myeloid differentiation primary response 88 antibody|Myeloid differentiation primary response gene (88) antibody|Myeloid differentiation primary response gene 88 antibody|Myeloid differentiation primary response gene antibody|Myeloid differentiation primary response protein MyD88 antibody|OTTHUMP00000161718 antibody|OTTHUMP00000208595 antibody|OTTHUMP00000209058 antibody|OTTHUMP00000209059 antibody|OTTHUMP00000209060 antibody|Anti-MyD88 antibody (ab2068)
SCBT cat No: sc-8197|
Rabbit polyclonal MyD88 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human MyD88
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 33kDa/Observed: Refer to Figures
MyD88 antibody was tube-contained.
MyD88 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.Contains 1 death domain.; Contains 1 TIR domain.
|Protein cellular localization|| |
Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (1-3). TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB that normally maintains NF-kappaB inactivity by sequestering it in the cytoplasm.MyD88 was originally isolated as a myeloid differentiation primary response gene that is rapidly induced upon IL-6 stimulated differentiation of M1 myeloleukemic cells into macrophages (4-6). It contains an amino-terminal death domain separated from a carboxyl-terminal TIR domain and functions as an adaptor in TLR/IL-1 receptor signaling (7). The death domain of MyD88 mediates interactions with the IRAK complex triggering a signaling cascade that includes the activation of NF-kappaB (8,9).
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|Product type|| |
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