Rabbit polyclonal MyD88 antibody (A0980)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MyD88 antibody (A0980)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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MYD88D antibody
Mutant myeloid differentiation primary response 88 antibody|MYD 88 antibody|Myd88 antibody|MYD88_HUMAN antibody|MYD88D antibody|Myeloid differentiation marker 88 antibody|Myeloid differentiation primary response 88 antibody|Myeloid differentiation primary response gene (88) antibody|Myeloid differentiation primary response gene 88 antibody|Myeloid differentiation primary response gene antibody|Myeloid differentiation primary response protein MyD88 antibody|OTTHUMP00000161718 antibody|OTTHUMP00000208595 antibody|OTTHUMP00000209058 antibody|OTTHUMP00000209059 antibody|OTTHUMP00000209060 antibody|Anti-MyD88 antibody (ab2068)

SCBT cat No: sc-8197|

Name

Rabbit polyclonal MyD88 antibody

Catalogue No.

A0980

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MyD88

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 33kDa/Observed: Refer to Figures

Formulation

MyD88 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MyD88 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MYD88D antibody

Database links

Human UniProt/Swiss-Prot:Q99836

Protein names

MYD88D

Protein function

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.Contains 1 death domain.; Contains 1 TIR domain.

Protein cellular localization

Cytoplasm .

Background

Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (1-3). TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB that normally maintains NF-kappaB inactivity by sequestering it in the cytoplasm.MyD88 was originally isolated as a myeloid differentiation primary response gene that is rapidly induced upon IL-6 stimulated differentiation of M1 myeloleukemic cells into macrophages (4-6). It contains an amino-terminal death domain separated from a carboxyl-terminal TIR domain and functions as an adaptor in TLR/IL-1 receptor signaling (7). The death domain of MyD88 mediates interactions with the IRAK complex triggering a signaling cascade that includes the activation of NF-kappaB (8,9).

Research area

All research areas>Lymphocyte Signaling>MyD88
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize MyD88 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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