Rabbit polyclonal MYL2 antibody (A5473)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MYL2 antibody (A5473)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MYL2 antibody.

Alternative names:

Check alternative names for the antibody

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MLC2 antibody, CMH10 antibody
Cardiac myosin light chain-2 antibody|Cardiac ventricular myosin light chain 2 antibody|CMH10 antibody|MLC 2v antibody|MLC-2 antibody|MLC-2v antibody|MLC2 antibody|MLRV_HUMAN antibody|MYL 2 antibody|MYL2 antibody|Myosin light chain 2 regulatory cardiac slow antibody|Myosin light polypeptide 2 regulatory cardiac slow antibody|Myosin regulatory light chain 2 antibody|Myosin regulatory light chain 2 ventricular/cardiac muscle isoform antibody|Regulatory light chain of myosin antibody|RLC of myosin antibody|Slow cardiac myosin regulatory light chain 2 antibody|ventricular/cardiac muscle isoform antibody|Anti-Myosin Light Chain 2 antibody [EPR3741] (ab92721)

SCBT cat No: sc-517205|sc-34490|

Name

Rabbit polyclonal MYL2 antibody

Catalogue No.

A5473

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MYL2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 19kDa/Observed: Refer to figures

Formulation

MYL2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MYL2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MLC2 antibody, CMH10 antibody

Database links

Human UniProt/Swiss-Prot:P10916

Protein names

MLC2, CMH10

Protein function

Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).

Protein sequence and domain

Contains 3 EF-hand domains.

Protein post-translational modifications

N-terminus is methylated by METTL11A/NTM1.; Phosphorylated by MYLK3 and MYLK2; promotes cardiac muscle contraction and function (By similarity). Dephosphorylated by PPP1CB complexed to PPP1R12B (By similarity). The phosphorylated form in adult is expressed as gradients across the heart from endocardium (low phosphorylation) to epicardium (high phosphorylation); regulates cardiac torsion and workload distribution (By similarity).

Protein cellular localization

Cytoplasm, myofibril, sarcomere, A band .

Background

Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.

Research area

All research areas>Structural Proteins>Myosin
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize MYL2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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