Rabbit polyclonal MYLIP antibody (A6166)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MYLIP antibody (A6166)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MYLIP antibody.

Alternative names:

Check alternative names for the antibody

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MIR antibody,MYLIP antibody
BM-023 antibody|BZF1 antibody|E3 ubiquitin protein ligase MYLIP antibody|E3 ubiquitin-protein ligase MYLIP antibody|Idol antibody|Inducible degrader of the LDL-receptor antibody|Lipoprotein receptor antibody|MIR antibody|MYLIP antibody|MYLIP_HUMAN antibody|Myosin regulatory light chain interacting protein antibody|PP5242 antibody|Anti-MYLIP antibody (ab74562)

SCBT cat No: sc-240724|

Name

Rabbit polyclonal MYLIP antibody

Catalogue No.

A6166

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MYLIP

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 50kDa/Observed: Refer to Figures

Formulation

MYLIP antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MYLIP antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MIR antibody,MYLIP antibody

Database links

Human UniProt/Swiss-Prot:Q8WY64

Protein names

MIR,MYLIP

Protein function

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Protein tissue specificity

Ubiquitously expressed.

Protein sequence and domain

The RING domain mediates ubiquitination and the neurite outgrowth inhibitory activity.; The FERM domain binds phospholipids and mediates lipoprotein receptors recognition at the plasma membrane through their cytoplasmic tails.; The RING-type zinc finger mediates the interaction with UBE2D E2 enzymes.Contains 1 FERM domain.; Contains 1 RING-type zinc finger.

Protein post-translational modifications

Autoubiquitinated.

Protein cellular localization

Cytoplasm . Cell membrane ; Peripheral membrane protein .

Background

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.

Research area

All research areas>Structural Proteins>MYLIP
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize MYLIP antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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