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Rabbit polyclonal MYO10 antibody (A8439)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal MYO10 antibody.
Check alternative names for the antibodyExpand
AW048724 antibody|D15Ertd600e antibody|FLJ10639 antibody|FLJ21066 antibody|FLJ22268 antibody|FLJ43256 antibody|KIAA0799 antibody|MGC131988 antibody|mKIAA0799 antibody|MYO10 antibody|MYO10_HUMAN antibody|Myosin X antibody|Myosin-X antibody|OTTMUSP00000022066 antibody|Unconventional myosin 10 antibody|Unconventional myosin X antibody|Unconventional myosin-10 antibody|Anti-MYO10 antibody – C-terminal (ab189259)
SCBT cat No: sc-166720|sc-30177|sc-23137|
Rabbit polyclonal MYO10 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human MYO10
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 237kDa/Observed: Refer to figures
MYO10 antibody was tube-contained.
MYO10 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.; Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity).
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Interaction between the motor domain and the tail leads to an inactive, monomeric conformation. Phospholipid binding via the PH domains leads to the formation of the active, dimeric form of the protein and strongly increases actin-dependent ATPase activity and motor activity (By similarity).; Interacts with membranes containing phosphatidylinositol-3,4,5-trisphosphate via the PH domains.; IQ 3 domain mediates high-affinity calcium-dependent binding to CALM3/CLP.; The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds. It can refold after extension suggesting an in vivo force-dependent function. The isolated SAH domain is monomeric; however, in its distal part seems to form a semirigid helical structure which overlaps with a region shown to mediate antiparallel coiled coil-mediated dimerization.Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.; Contains 1 FERM domain.; Contains 3 IQ domains.; Contains 1 myosin motor domain.; Contains 1 MyTH4 domain.; Contains 2 PH domains.
|Protein post-translational modifications|| |
The initiator methionine for isoform Headless is removed.
|Protein cellular localization|| |
Cytoplasm, cytosol . Cell projection, lamellipodium . Cell projection, ruffle . Cytoplasm, cytoskeleton . Cell projection, filopodium tip . Cytoplasm, cell cortex . Cell projection, filopodium membrane ; Peripheral membrane protein . Note: May be in an inactive, monomeric conformation in the cytosol. Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Undergoes forward and rearward movements within filopodia. Interacts with microtubules.
This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis.
AntibodyPlus can customize MYO10 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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