Rabbit polyclonal MYOG antibody (A6664)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MYOG antibody (A6664)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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MYF4 antibody, myf-4 antibody, bHLHc3 antibody
bHLHc3 antibody|cb553 antibody|Class C basic helix-loop-helix protein 3 antibody|MYF 4 antibody|Myf-4 antibody|MYF4 antibody|MYOG antibody|MYOG_HUMAN antibody|Myogenic factor 4 antibody|Myogenic factor 4 myogenin antibody|Myogenin antibody|Myogenin myogenin factor 4 antibody|OTTHUMP00000039094 antibody|Anti-Myogenin antibody [F5D] (ab1835)

SCBT cat No: sc-52903|sc-13137|sc-12732|sc-31945|sc-398002|sc-576|sc-31943|

Name

Rabbit polyclonal MYOG antibody

Catalogue No.

A6664

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MYOG

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 25kDa/Observed: Refer to Figures

Formulation

MYOG antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MYOG antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MYF4 antibody, myf-4 antibody, bHLHc3 antibody

Database links

Human UniProt/Swiss-Prot:P15173

Protein names

MYF4, myf-4, bHLHc3

Protein function

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).

Protein sequence and domain

Contains 1 bHLH (basic helix-loop-helix) domain.

Protein post-translational modifications

Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles (By similarity).

Protein cellular localization

Nucleus. Note: Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos.

Background

Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle.

Research area

All research areas>Transcription Regulators>Myogenin
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize MYOG antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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