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Rabbit polyclonal NAB2 antibody (A5827)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal NAB2 antibody.
Check alternative names for the antibodyExpand
EGR 1 binding protein 2 antibody|EGR-1-binding protein 2 antibody|EGR1 binding protein 2 antibody|MADER antibody|Melanoma associated delayed early response protein antibody|Melanoma-associated delayed early response protein antibody|MGC75085 antibody|Nab 2 antibody|nab2 antibody|NAB2_HUMAN antibody|NGFI A binding protein 2 (EGR1 binding protein 2) antibody|NGFI A binding protein 2 antibody|NGFI-A-binding protein 2 antibody|Protein MADER antibody|Anti-Nab2 antibody (ab166810)
SCBT cat No: sc-23867|sc-12151|sc-398123|sc-12153|sc-28323|sc-48416|sc-22815|
Rabbit polyclonal NAB2 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human NAB2
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 56kDa/Observed: Refer to Figures
NAB2 antibody was tube-contained.
NAB2 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).
|Protein tissue specificity|| |
Widely expressed at low levels. Highly expressed in melanoma cell lines.
|Protein sequence and domain|| |
The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.; The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.Belongs to the NAB family.
|Protein post-translational modifications|| |
Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.
|Protein cellular localization|| |
Nucleus . Note: Isoform 2 is not localized to the nucleus.
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
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|Product type|| |
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