Rabbit polyclonal NAB2 antibody (A5827)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NAB2 antibody (A5827)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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MADER antibody
EGR 1 binding protein 2 antibody|EGR-1-binding protein 2 antibody|EGR1 binding protein 2 antibody|MADER antibody|Melanoma associated delayed early response protein antibody|Melanoma-associated delayed early response protein antibody|MGC75085 antibody|Nab 2 antibody|nab2 antibody|NAB2_HUMAN antibody|NGFI A binding protein 2 (EGR1 binding protein 2) antibody|NGFI A binding protein 2 antibody|NGFI-A-binding protein 2 antibody|Protein MADER antibody|Anti-Nab2 antibody (ab166810)

SCBT cat No: sc-23867|sc-12151|sc-398123|sc-12153|sc-28323|sc-48416|sc-22815|

Name

Rabbit polyclonal NAB2 antibody

Catalogue No.

A5827

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NAB2

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 56kDa/Observed: Refer to Figures

Formulation

NAB2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NAB2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MADER antibody

Database links

Human UniProt/Swiss-Prot:Q15742

Protein names

MADER

Protein function

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).

Protein tissue specificity

Widely expressed at low levels. Highly expressed in melanoma cell lines.

Protein sequence and domain

The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.; The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.Belongs to the NAB family.

Protein post-translational modifications

Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.

Protein cellular localization

Nucleus . Note: Isoform 2 is not localized to the nucleus.

Background

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Research area

All research areas>Transcription Regulators>NAB
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize NAB2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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