Rabbit polyclonal NAE1 antibody (A4254)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NAE1 antibody (A4254)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:1000 – 1:4000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal NAE1 antibody.

Alternative names:

Check alternative names for the antibody

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HPP1 antibody, ula-1 antibody, APPBP1 antibody, A-116A10.1 antibody
59 kDa antibody|A 116A10.1 antibody|Amyloid beta precursor protein binding protein 1 59kD antibody|Amyloid beta precursor protein binding protein 1 59kDa antibody|Amyloid beta precursor protein binding protein 1 antibody|Amyloid beta precursor protein binding protein 1, 59 kDa antibody|Amyloid beta precursor protein-binding protein 1 antibody|Amyloid protein binding protein 1 antibody|Amyloid protein-binding protein 1 antibody|APP BP1 antibody|APP-BP1 antibody|APPBP 1 antibody|APPBP1 antibody|HPP 1 antibody|HPP1 antibody|NAE 1 antibody|NAE1 antibody|NEDD8 activating enzyme E1 regulatory subunit antibody|NEDD8 activating enzyme E1 subunit 1 antibody|NEDD8 activating enzyme E1 subunit antibody|NEDD8-activating enzyme E1 regulatory subunit antibody|Proto oncogene protein 1 antibody|Proto-oncogene protein 1 antibody|Protooncogene protein 1 antibody|ula 1 antibody|ULA1_HUMAN antibody|Anti-APPBP1 antibody [EPR15732] (ab187142)

SCBT cat No: sc-135839|sc-390002|sc-366048|

Name

Rabbit polyclonal NAE1 antibody

Catalogue No.

A4254

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NAE1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:1000 – 1:4000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 60kDa/Observed: Refer to figures

Formulation

NAE1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NAE1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HPP1 antibody, ula-1 antibody, APPBP1 antibody, A-116A10.1 antibody

Database links

Human UniProt/Swiss-Prot:Q13564

Protein names

HPP1, ula-1, APPBP1, A-116A10.1

Protein function

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.

Protein tissue specificity

Ubiquitous in fetal tissues. Expressed throughout the adult brain.

Protein sequence and domain

Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.

Protein post-translational modifications

Ubiquitinated by TRIP12, leading to its degradation by the proteasome.

Protein cellular localization

Cell membrane . Note: Colocalizes with APP in lipid rafts.

Background

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer’s disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Neurobiology>APPBP
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize NAE1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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