Rabbit polyclonal NAMPT antibody (A0256)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NAMPT antibody (A0256)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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NAMPT antibody,1110035O14Rik antibody,DKFZp666B131 antibody,MGC117256 antibody,PBEF antibody,PBEF1 antibody,VF antibody,VISFATIN antibody
1110035O14Rik antibody|AI314458 antibody|AI480535 antibody|DKFZP666B131 antibody|EC 2.4.2.12 antibody|MGC117256 antibody|NAmPRTase antibody|Nampt antibody|NAMPT_HUMAN antibody|Nicotinamide phosphoribosyltransferase antibody|PBEF 1 antibody|PBEF antibody|PBEF1 antibody|Pre B cell colony enhancing factor 1 antibody|Pre B cell colony enhancing factor antibody|Pre B cell enhancing factor antibody|Pre-B cell-enhancing factor antibody|Pre-B-cell colony-enhancing factor 1 antibody|VF antibody|Visfatin antibody|Anti-Visfatin antibody (ab45890)

SCBT cat No: sc-130058|sc-46440|sc-166866|sc-393444|sc-393443|sc-393510|sc-166946|sc-67020|

Name

Rabbit polyclonal NAMPT antibody

Catalogue No.

A0256

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NAMPT

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 52kDa/Observed: Refer to Figures

Formulation

NAMPT antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NAMPT antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NAMPT antibody,1110035O14Rik antibody,DKFZp666B131 antibody,MGC117256 antibody,PBEF antibody,PBEF1 antibody,VF antibody,VISFATIN antibody

Database links

Human UniProt/Swiss-Prot:P43490

Protein names

NAMPT,1110035O14Rik,DKFZp666B131,MGC117256,PBEF,PBEF1,VF,VISFATIN

Protein function

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).

Protein tissue specificity

Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.

Protein sequence and domain

Belongs to the NAPRTase family.

Protein cellular localization

Nucleus . Cytoplasm . Secreted . Note: Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum.

Background

Nicotinamide phosphoribosyltransferase(NAMPT) has two usual synonyms termed Visfatin and PBEF. Its primary role is to catalyze the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD, which is the rate limiting component in the mammalian NAD biosynthesis pathway. NAMPT is localized in cytoplasm and expressed in large amounts in bone marrow, liver tissue, and muscle tissues. NAMPT inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. NAMPT levels are altered in plasma of patients with type 2 diabetes mellitus (T2DM), and it is now evidenced that NAMPT may plays a role in lipid metabolism.

Research area

All research areas>Lymphocyte Signaling>PBEF
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize NAMPT antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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