Rabbit polyclonal NBN antibody (A7703)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NBN antibody (A7703)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ATV antibody, NBS antibody, P95 antibody, NBS1 antibody, AT-V1 antibody, AT-V2 antibody
AT V1 antibody|AT V2 antibody|ATV antibody|Cell cycle regulatory protein p95 antibody|FLJ10155 antibody|MGC87362 antibody|Nbn antibody|NBN_HUMAN antibody|NBS 1 antibody|NBS antibody|NBS1 antibody|Nibrin antibody|Nijmegen breakage syndrome 1 (nibrin) antibody|Nijmegen breakage syndrome antibody|Nijmegen breakage syndrome protein 1 antibody|p95 antibody|p95 protein of the MRE11/RAD50 complex antibody|Anti-p95 NBS1 antibody [Y112] – ChIP Grade (ab32074)

SCBT cat No: sc-56166|sc-374168|sc-515069|sc-8580|sc-11431|sc-8579|sc-65148|sc-136003|

Name

Rabbit polyclonal NBN antibody

Catalogue No.

A7703

Reactivity

Human

Immunogen

A synthetic peptide of human NBN

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 85kDa/Observed: Refer to figures

Formulation

NBN antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NBN antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ATV antibody, NBS antibody, P95 antibody, NBS1 antibody, AT-V1 antibody, AT-V2 antibody

Database links

Human UniProt/Swiss-Prot:O60934

Protein names

ATV, NBS, P95, NBS1, AT-V1, AT-V2

Protein function

Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3′-5′ exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3′ overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.

Protein tissue specificity

Ubiquitous. Expressed at high levels in testis.

Protein sequence and domain

The FHA and BRCT domains are likely to have a crucial role for both binding to histone H2AFX and for relocalization of MRE11/RAD50 complex to the vicinity of DNA damage.; The C-terminal domain contains a MRE11-binding site, and this interaction is required for the nuclear localization of the MRN complex.; The EEXXXDDL motif at the C-terminus is required for the interaction with ATM and its recruitment to sites of DNA damage and promote the phosphorylation of ATM substrates, leading to the events of DNA damage response.Contains 1 BRCT domain.; Contains 1 FHA domain.

Protein post-translational modifications

Phosphorylated by ATM in response of ionizing radiation, and such phosphorylation is responsible intra-S phase checkpoint control and telomere maintenance.

Protein cellular localization

Nucleus . Nucleus, PML body . Chromosome, telomere . Note: Localizes to discrete nuclear foci after treatment with genotoxic agents.

Background

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Research area

All research areas>Tumor Suppressor/Apoptosis>Nibrin
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize NBN antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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