Rabbit polyclonal NCF1 antibody (A1148)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NCF1 antibody (A1148)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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NCF1 antibody,FLJ79451 antibody,NCF1A antibody,NOXO2 antibody,SH3PXD1A antibody,p47phox antibody
47 kDa autosomal chronic granulomatous disease protein antibody|47 kDa neutrophil oxidase factor antibody|NADPH oxidase organizer 2 antibody|NCF 47K antibody|NCF-1 antibody|NCF-47K antibody|Ncf1 antibody|NCF1_HUMAN antibody|Neutrophil cytosol factor 1 antibody|Neutrophil cytosolic factor 1 antibody|neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1) antibody|Neutrophil NADPH oxidase factor 1 antibody|Nox organizer 2 antibody|Nox organizing protein 2 antibody|Nox-organizing protein 2 antibody|NOXO2 antibody|p47 phox antibody|p47-phox antibody|SH3 and PX domain containing protein 1A antibody|SH3 and PX domain-containing protein 1A antibody|SH3PXD1A antibody|Anti-NCF1 antibody (ab795)

SCBT cat No: sc-17844|sc-7660|sc-17845|sc-23492|sc-14015|

Name

Rabbit polyclonal NCF1 antibody

Catalogue No.

A1148

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human NCF1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to Figures

Formulation

NCF1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NCF1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NCF1 antibody,FLJ79451 antibody,NCF1A antibody,NOXO2 antibody,SH3PXD1A antibody,p47phox antibody

Database links

Human UniProt/Swiss-Prot:P14598

Protein names

NCF1,FLJ79451,NCF1A,NOXO2,SH3PXD1A,p47phox

Protein function

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Protein tissue specificity

Detected in peripheral blood monocytes and neutrophils (at protein level).

Protein sequence and domain

The PX domain mediates interaction with phosphatidylinositol 3,4-bisphosphate and other anionic phospholipids. In the autoinhibited, unphosphorylated state an intramolecular interaction with the C-terminal SH3 domain precludes phospholipid binding and interaction with CYBA. Phosphorylation disrupts the autoinhibited state.Contains 1 PX (phox homology) domain.; Contains 2 SH3 domains.

Protein post-translational modifications

Phosphorylated by PRKCD; phosphorylation induces activation of NCF1 and NADPH oxidase activity.

Protein cellular localization

Cytoplasm, cytosol . Membrane ; Peripheral membrane protein ; Cytoplasmic side .

Background

The phagocytic NADPH oxidase is a multiprotein enzyme that catalyzes the reduction of oxygen to superoxide in response to pathogenic invasion. The NADPH oxidase consists of 6 subunits, including the membrane-bound p91 phox and p22 phox heterodimers (also known as cytochrome b558), the cytosolic complex of p40phox, p47phox and p67phox, and the small GTPase Rac2. Activation of NADPH oxidase is initiated by cytosolic complex phosphorylation, which induces a conformational change that leads to the translocation of the cytosolic complex to the membrane and formation of an active enzyme with cytochrome b558 (1). Defects in p47phox, often resulting from recombination between p47phox and a nearby homologous pseudogene, cause chronic granulomatous disease (2-4). Elevated oxidative stress due to increased myocardial NADPH oxidase activity may be a contributing factor in heart failure (5,6).

Research area

All research areas>Synthesis and Degradation>p47-phox
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize NCF1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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