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Rabbit polyclonal NCF1 antibody (A1148)
$69.00–$259.00
Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.
Rabbit polyclonal NCF1 antibody (A1148)
Supplier: ABclonal Inc.
Recommended applications: WB
Recommended dilution:
WB 1:500 – 1:2000
Recommended protocols: check protocols
Image descriptions:
Click or hover above images to see image description for Rabbit polyclonal NCF1 antibody.
Alternative names:
Check alternative names for the antibody
ExpandNCF1 antibody,FLJ79451 antibody,NCF1A antibody,NOXO2 antibody,SH3PXD1A antibody,p47phox antibody
47 kDa autosomal chronic granulomatous disease protein antibody|47 kDa neutrophil oxidase factor antibody|NADPH oxidase organizer 2 antibody|NCF 47K antibody|NCF-1 antibody|NCF-47K antibody|Ncf1 antibody|NCF1_HUMAN antibody|Neutrophil cytosol factor 1 antibody|Neutrophil cytosolic factor 1 antibody|neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1) antibody|Neutrophil NADPH oxidase factor 1 antibody|Nox organizer 2 antibody|Nox organizing protein 2 antibody|Nox-organizing protein 2 antibody|NOXO2 antibody|p47 phox antibody|p47-phox antibody|SH3 and PX domain containing protein 1A antibody|SH3 and PX domain-containing protein 1A antibody|SH3PXD1A antibody|Anti-NCF1 antibody (ab795)
SCBT cat No: sc-17844|sc-7660|sc-17845|sc-23492|sc-14015|
| Name | Rabbit polyclonal NCF1 antibody |
|---|---|
| Catalogue No. | A1148 |
| Reactivity | Human, Mouse |
| Immunogen | Recombinant protein of human NCF1 |
| Host | Rabbit |
| Applications | WB |
| Recommended dilution | WB 1:500 – 1:2000 |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Molecular weight | Predicted: 45kDa/Observed: Refer to Figures |
| Formulation | NCF1 antibody was tube-contained. |
| Purification | NCF1 antibody was purified using affinity purification. |
| Storage | Store at -20 Celsius degree. Avoid freeze / thaw cycles. |
| Alternative antibody names | NCF1 antibody,FLJ79451 antibody,NCF1A antibody,NOXO2 antibody,SH3PXD1A antibody,p47phox antibody |
| Database links | Human UniProt/Swiss-Prot:P14598 |
| Protein names | NCF1,FLJ79451,NCF1A,NOXO2,SH3PXD1A,p47phox |
| Protein function | NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). |
| Protein tissue specificity | Detected in peripheral blood monocytes and neutrophils (at protein level). |
| Protein sequence and domain | The PX domain mediates interaction with phosphatidylinositol 3,4-bisphosphate and other anionic phospholipids. In the autoinhibited, unphosphorylated state an intramolecular interaction with the C-terminal SH3 domain precludes phospholipid binding and interaction with CYBA. Phosphorylation disrupts the autoinhibited state.Contains 1 PX (phox homology) domain.; Contains 2 SH3 domains. |
| Protein post-translational modifications | Phosphorylated by PRKCD; phosphorylation induces activation of NCF1 and NADPH oxidase activity. |
| Protein cellular localization | Cytoplasm, cytosol . Membrane ; Peripheral membrane protein ; Cytoplasmic side . |
| Background | The phagocytic NADPH oxidase is a multiprotein enzyme that catalyzes the reduction of oxygen to superoxide in response to pathogenic invasion. The NADPH oxidase consists of 6 subunits, including the membrane-bound p91 phox and p22 phox heterodimers (also known as cytochrome b558), the cytosolic complex of p40phox, p47phox and p67phox, and the small GTPase Rac2. Activation of NADPH oxidase is initiated by cytosolic complex phosphorylation, which induces a conformational change that leads to the translocation of the cytosolic complex to the membrane and formation of an active enzyme with cytochrome b558 (1). Defects in p47phox, often resulting from recombination between p47phox and a nearby homologous pseudogene, cause chronic granulomatous disease (2-4). Elevated oxidative stress due to increased myocardial NADPH oxidase activity may be a contributing factor in heart failure (5,6). |
| Research area | All research areas>Synthesis and Degradation>p47-phox |
| Note | AntibodyPlus can customize NCF1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation. |
| Product type | Primary antibody |
| Supplier | ABclonal Inc. |
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