Rabbit polyclonal NCF2 antibody (A1178)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,ICC,IF,IP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NCF2 antibody (A1178)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,ICC,IF,IP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 ICC 1:20 – 1:100 IF 1:50 – 1:200 IP 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal NCF2 antibody.

Alternative names:

Check alternative names for the antibody

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NCF2 antibody,FLJ93058 antibody,NCF-2 antibody,NOXA2 antibody,P67-PHOX antibody,P67PHOX antibody
67 kDa neutrophil oxidase factor antibody|Chronic granulomatous disease autosomal 2 antibody|FLJ93058 antibody|NADPH oxidase activator 2 antibody|NCF-2 antibody|Ncf2 antibody|NCF2_HUMAN antibody|Neutrophil cytosol factor 2 antibody|Neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2) antibody|Neutrophil NADPH oxidase factor 2 antibody|NOXA2 antibody|P67 PHOX antibody|p67-phox antibody|p67phox antibody|Anti-NOXA2/p67phox antibody [EPR5064] (ab109366)

SCBT cat No: sc-7662|sc-374510|sc-15342|sc-7663|

Name

Rabbit polyclonal NCF2 antibody

Catalogue No.

A1178

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NCF2

Host

Rabbit

Applications

WB, IHC, ICC, IF, IP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
ICC 1:20 – 1:100
IF 1:50 – 1:200
IP 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 60kDa/Observed: Refer to Figures

Formulation

NCF2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NCF2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NCF2 antibody,FLJ93058 antibody,NCF-2 antibody,NOXA2 antibody,P67-PHOX antibody,P67PHOX antibody

Database links

Human UniProt/Swiss-Prot:P19878

Protein names

NCF2,FLJ93058,NCF-2,NOXA2,P67-PHOX,P67PHOX

Protein function

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Protein sequence and domain

The OPR/PB1 domain mediates the association with NCF4/p40-PHOX.Belongs to the NCF2/NOXA1 family.; Contains 1 PB1 domain.; Contains 2 SH3 domains.; Contains 3 TPR repeats.

Protein cellular localization

Cytoplasm.

Background

The phagocytic NADPH oxidase is a multiprotein enzyme that catalyzes the reduction of oxygen to superoxide in response to pathogenic invasion. The NADPH oxidase consists of 6 subunits, including the membrane-bound p91 phox and p22 phox heterodimers (also known as cytochrome b558), the cytosolic complex of p40phox, p47phox and p67phox, and the small GTPase Rac2. Activation of NADPH oxidase is initiated by cytosolic complex phosphorylation, which induces a conformational change that leads to the translocation of the cytosolic complex to the membrane and formation of an active enzyme with cytochrome b558 (1). Defects in p47phox, often resulting from recombination between p47phox and a nearby homologous pseudogene, cause chronic granulomatous disease (2-4). Elevated oxidative stress due to increased myocardial NADPH oxidase activity may be a contributing factor in heart failure (5,6).p67phox appears to coordinate assembly of NAPDH oxidase as it associates with multiple subunits as well as the alpha subunit of heterotrimeric G proteins (7). Mutations in the corresponding p67phox gene are also associated with a form of autosomal recessive chronic granulomatous disease (8).

Note

AntibodyPlus can customize NCF2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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