Rabbit Polyclonal NCOA2 antibody (A10280)

$99.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal NCOA2 antibody (A10280)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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SRC2 antibody; TIF2 antibody; GRIP1 antibody; KAT13C antibody; NCoA-2 antibody; bHLHe75
bHLHe75 antibody|Class E basic helix-loop-helix protein 75 antibody|glucocorticoid receptor interacting protein 1 antibody|GRIP 1 antibody|GRIP1 antibody|hTIF2 antibody|MED1 antibody|MGC138808 antibody|NCoA 2 antibody|NCoA-2 antibody|Ncoa2 antibody|NCOA2_HUMAN antibody|Nuclear receptor coactivator 2 antibody|Oncogene FGR antibody|p160 antibody|SRC 2 antibody|src2 antibody|Steroid receptor coactivator 2 antibody|TIF 2 antibody|TIF2 antibody|Transcriptional intermediary factor 2 antibody|Anti-KAT13C / NCOA2 antibody – ChIP Grade (ab9261)

SCBT cat No: sc-136244|sc-135931|sc-17643|sc-6976|sc-365827|sc-6264|

Name

Rabbit Polyclonal NCOA2 antibody

Catalogue No.

A10280

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human NCOA2

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

159kDa

Formulation

NCOA2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SRC2 antibody; TIF2 antibody; GRIP1 antibody; KAT13C antibody; NCoA-2 antibody; bHLHe75

Protein names

SRC2; TIF2; GRIP1; KAT13C; NCoA-2; bHLHe75

Protein function

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Protein sequence and domain

Belongs to the SRC/p160 nuclear receptor coactivator family.; Contains 1 bHLH (basic helix-loop-helix) domain.; Contains 1 PAS (PER-ARNT-SIM) domain. Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.; The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.; Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.

Protein cellular localization

Nucleus.

Background

The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010]

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Steroid-Receptors/">Steroid Receptors</a>><a href="http://antibodyplus.com/product-tag/GRIP-1/">GRIP-1</a><br><a href="http://antibodyplus.com/product-tag/Steroid-Receptors/"&gt; (View all antibody categories related to Steroid Receptors)</a>

Note

AntibodyPlus can customize NCOA2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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