Rabbit polyclonal NCOR1 antibody (A7046)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NCOR1 antibody (A7046)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal NCOR1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

N-CoR antibody, TRAC1 antibody, N-CoR1 antibody, hN-CoR antibody, PPP1R109 antibody
hN CoR antibody|hNCoR antibody|KIAA1047 antibody|N CoR antibody|N Cor/SMRT corepressor Rip13 antibody|N CoR1 antibody|N-CoR antibody|N-CoR1 antibody|NCOR 1 antibody|NCoR antibody|Ncor1 antibody|NCOR1_HUMAN antibody|Nuclear receptor co repressor 1 antibody|Nuclear receptor corepressor 1 antibody|Retinoid X receptor interacting protein 13 antibody|RIP13 antibody|Rxrip13 antibody|thyroid hormone and retinoic acid receptor associated corepressor 1 antibody|TRAC 1 antibody|TRAC1 antibody|Anti-Nuclear Receptor Corepressor NCoR antibody – ChIP Grade (ab24552)

SCBT cat No: sc-293154|sc-1609|sc-8994|sc-1611|

Name

Rabbit polyclonal NCOR1 antibody

Catalogue No.

A7046

Reactivity

Human

Immunogen

Recombinant protein of human NCOR1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 270kDa/Observed: Refer to figures

Formulation

NCOR1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NCOR1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

N-CoR antibody, TRAC1 antibody, N-CoR1 antibody, hN-CoR antibody, PPP1R109 antibody

Database links

Human UniProt/Swiss-Prot:O75376

Protein names

N-CoR, TRAC1, N-CoR1, hN-CoR, PPP1R109

Protein function

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.

Protein sequence and domain

The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).; The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity).Belongs to the N-CoR nuclear receptor corepressors family.; Contains 2 SANT domains.

Protein post-translational modifications

Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.

Protein cellular localization

Nucleus .

Background

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.

Research area

All research areas>Steroid Receptors>N-CoR
(View all antibody categories related to Steroid Receptors)

Note

AntibodyPlus can customize NCOR1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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