Rabbit polyclonal NCOR2 antibody (A8388)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NCOR2 antibody (A8388)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal NCOR2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

SMRT antibody, TRAC antibody, CTG26 antibody, SMRTE antibody, TRAC1 antibody, N-CoR2 antibody, TNRC14 antibody, TRAC-1 antibody, SMAP270 antibody, SMRTE-tau antibody
CTG 26 antibody|CTG repeat protein 26 antibody|CTG26 antibody|N CoR2 antibody|N-CoR2 antibody|NCoR 2 antibody|Ncor2 antibody|NCOR2_HUMAN antibody|Nuclear Receptor Co-Repressor 2 antibody|Nuclear receptor corepressor 2 antibody|retinoic-acid-receptor-associated corepressor antibody|Silencing Mediator for Retanoid and Thyroid Hormone Receptors antibody|Silencing mediator of retinoic acid and thyroid hormone receptor antibody|SMAP 270 antibody|SMAP270 antibody|SMRT antibody|SMRTE antibody|SMRTE tau antibody|T3 receptor associating factor antibody|T3 receptor-associating factor antibody|Thyroid retinoic acid receptor associated corepressor antibody|Thyroid- antibody|TNRC 14 antibody|TNRC14 antibody|TRAC 1 antibody|TRAC antibody|TRAC1 antibody|Anti-NCOR2 antibody – ChIP Grade (ab24551)

SCBT cat No:

Name

Rabbit polyclonal NCOR2 antibody

Catalogue No.

A8388

Reactivity

Human

Immunogen

Recombinant protein of human NCOR2

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 275kDa/Observed: Refer to figures

Formulation

NCOR2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NCOR2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SMRT antibody, TRAC antibody, CTG26 antibody, SMRTE antibody, TRAC1 antibody, N-CoR2 antibody, TNRC14 antibody, TRAC-1 antibody, SMAP270 antibody, SMRTE-tau antibody

Database links

Human UniProt/Swiss-Prot:Q9Y618

Protein names

SMRT, TRAC, CTG26, SMRTE, TRAC1, N-CoR2, TNRC14, TRAC-1, SMAP270, SMRTE-tau

Protein function

Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.

Protein tissue specificity

Ubiquitous. High levels of expression are detected in lung, spleen and brain.

Protein sequence and domain

The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).; The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.Belongs to the N-CoR nuclear receptor corepressors family.; Contains 2 SANT domains.

Protein cellular localization

Nucleus.

Background

This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.

Note

AntibodyPlus can customize NCOR2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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