Rabbit polyclonal NDC80 antibody (A5411)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NDC80 antibody (A5411)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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HEC antibody, HEC1 antibody, TID3 antibody, KNTC2 antibody, HsHec1 antibody, hsNDC80 antibody
from Entrez Gene ; antibody|HEC antibody|Highly expressed in cancer antibody|Highly expressed in cancer protein antibody|Highly expressed in cancer rich in leucine heptad repeats antibody|HsHec1 antibody|hsNDC80 antibody|Kinetochore associated 2 antibody|Kinetochore associated protein 2 antibody|Kinetochore protein Hec1 antibody|Kinetochore protein NDC80 homolog antibody|Kinetochore-associated protein 2 antibody|KNTC2 antibody|ndc80 antibody|NDC80 homolog kinetochore complex component antibody|NDC80 kinetochore complex component homolog antibody|NDC80, S. cerevisiae, homolog of antibody|NDC80_HUMAN antibody|Retinoblastoma associated protein HEC antibody|Retinoblastoma-associated protein HEC antibody|TID3 antibody|Anti-HEC1 antibody [9G3] (ab3613)

SCBT cat No: sc-135934|sc-515550|

Name

Rabbit polyclonal NDC80 antibody

Catalogue No.

A5411

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NDC80

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 74kDa/Observed: Refer to Figures

Formulation

NDC80 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NDC80 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HEC antibody, HEC1 antibody, TID3 antibody, KNTC2 antibody, HsHec1 antibody, hsNDC80 antibody

Database links

Human UniProt/Swiss-Prot:O14777

Protein names

HEC, HEC1, TID3, KNTC2, HsHec1, hsNDC80

Protein function

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity . Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore . The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules .

Protein sequence and domain

Belongs to the NDC80/HEC1 family.

Protein post-translational modifications

Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.

Protein cellular localization

Nucleus. Chromosome, centromere, kinetochore. Note: Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.

Background

This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation.

Research area

All research areas>Cell Cycle Proteins>Hec1
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize NDC80 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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