Rabbit polyclonal NDEL1 antibody (A5776)

$69.00$259.00

Reactivity: Human,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NDEL1 antibody (A5776)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

EOPA antibody, NDE2 antibody, NUDEL antibody, MITAP1 antibody, NDE1L1 antibody
A. nidulans antibody|DKFZp451M0318 antibody|ENDOOLIGOPEPTIDASE A antibody|EOPA antibody|MITAP 1 antibody|MITAP1 antibody|Mitosin associated protein 1 antibody|Mitosin associated protein MITAP1 antibody|Mitosin-associated protein 1 antibody|Ndel 1 antibody|NDEL1 antibody|NDEL1_HUMAN antibody|Nuclear distribution gene E like homolog 1 antibody|Nuclear distribution protein nudE like 1 antibody|Nuclear distribution protein nudE-like 1 antibody|NUDE like protein antibody|NudE nuclear distribution gene E homolog like 1 A. nidulans antibody|NudE nuclear distribution gene E homolog like 1 antibody|NUDEL antibody|Protein Nudel antibody|Anti-Nudel antibody (ab25959)

SCBT cat No: sc-365094|

Name

Rabbit polyclonal NDEL1 antibody

Catalogue No.

A5776

Reactivity

Human, Rat

Immunogen

Recombinant protein of human NDEL1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 38kDa/Observed: Refer to Figures

Formulation

NDEL1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NDEL1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

EOPA antibody, NDE2 antibody, NUDEL antibody, MITAP1 antibody, NDE1L1 antibody

Database links

Human UniProt/Swiss-Prot:Q9GZM8

Protein names

EOPA, NDE2, NUDEL, MITAP1, NDE1L1

Protein function

Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

Protein tissue specificity

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.

Protein sequence and domain

Belongs to the nudE family.

Protein post-translational modifications

Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE.; Palmitoylation at Cys-273 reduces affinity for dynein.

Protein cellular localization

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note: Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner.

Background

This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X.

Note

AntibodyPlus can customize NDEL1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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