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Rabbit polyclonal NEFH antibody (A8442)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal NEFH antibody.
Check alternative names for the antibodyExpand
200 kDa neurofilament protein antibody|CMT2CC antibody|Nefh antibody|Neurofilament heavy polypeptide 200kDa antibody|Neurofilament heavy polypeptide antibody|Neurofilament triplet H protein antibody|NF H antibody|NF-H antibody|NFH antibody|NFH_HUMAN antibody|Anti-Neurofilament heavy polypeptide antibody (ab8135)
SCBT cat No: sc-20014|sc-133165|sc-137009|sc-22909|sc-20112|sc-133237|sc-32729|sc-58553|sc-56575|sc-71678|sc-20012|sc-12980|sc-58559|sc-390732|sc-25652|
Rabbit polyclonal NEFH antibody
|Catalogue No.|| |
Recombinant protein of human NEFH
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 112kDa/Observed: Refer to figures
NEFH antibody was tube-contained.
NEFH antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.
|Protein sequence and domain|| |
Belongs to the intermediate filament family.
|Protein post-translational modifications|| |
There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.; Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.; Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.
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|Product type|| |
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