Rabbit polyclonal NEFH antibody (A8442)

$69.00$259.00

Reactivity: Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NEFH antibody (A8442)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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NFH antibody
200 kDa neurofilament protein antibody|CMT2CC antibody|Nefh antibody|Neurofilament heavy polypeptide 200kDa antibody|Neurofilament heavy polypeptide antibody|Neurofilament triplet H protein antibody|NF H antibody|NF-H antibody|NFH antibody|NFH_HUMAN antibody|Anti-Neurofilament heavy polypeptide antibody (ab8135)

SCBT cat No: sc-20014|sc-133165|sc-137009|sc-22909|sc-20112|sc-133237|sc-32729|sc-58553|sc-56575|sc-71678|sc-20012|sc-12980|sc-58559|sc-390732|sc-25652|

Name

Rabbit polyclonal NEFH antibody

Catalogue No.

A8442

Reactivity

Mouse, Rat

Immunogen

Recombinant protein of human NEFH

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 112kDa/Observed: Refer to figures

Formulation

NEFH antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NEFH antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NFH antibody

Database links

Human UniProt/Swiss-Prot:P12036

Protein names

NFH

Protein function

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.

Protein sequence and domain

Belongs to the intermediate filament family.

Protein post-translational modifications

There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.; Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.; Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.

Background

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.

Research area

All research areas>Neurobiology>NF
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize NEFH antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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