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Rabbit polyclonal NEK3 antibody (A6665)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal NEK3 antibody.
Check alternative names for the antibodyExpand
HSPK 36 antibody|Serine/threonine protein kinase Nek3 antibody|Serine/threonine-protein kinase Nek3 antibody|Anti-NEK3 antibody (ab83221)
SCBT cat No: sc-100402|sc-390872|
Rabbit polyclonal NEK3 antibody
|Catalogue No.|| |
Recombinant protein of human NEK3
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 57kDa/Observed: Refer to figures
NEK3 antibody was tube-contained.
NEK3 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.
|Protein tissue specificity|| |
Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.; Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Phosphorylation at Thr-479 regulates its catalytic activity.
|Protein cellular localization|| |
Cytoplasm . Cell projection, axon .
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.
AntibodyPlus can customize NEK3 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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