Rabbit polyclonal NEK3 antibody (A6665)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal NEK3 antibody (A6665)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal NEK3 antibody.

Alternative names:

Check alternative names for the antibody

Expand

HSPK36 antibody
HSPK 36 antibody|Serine/threonine protein kinase Nek3 antibody|Serine/threonine-protein kinase Nek3 antibody|Anti-NEK3 antibody (ab83221)

SCBT cat No: sc-100402|sc-390872|

Name

Rabbit polyclonal NEK3 antibody

Catalogue No.

A6665

Reactivity

Human

Immunogen

Recombinant protein of human NEK3

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 57kDa/Observed: Refer to figures

Formulation

NEK3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NEK3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HSPK36 antibody

Database links

Human UniProt/Swiss-Prot:P51956

Protein names

HSPK36

Protein function

Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.

Protein tissue specificity

Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain.

Protein sequence and domain

Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.; Contains 1 protein kinase domain.

Protein post-translational modifications

Phosphorylation at Thr-479 regulates its catalytic activity.

Protein cellular localization

Cytoplasm . Cell projection, axon .

Background

This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Kinases and Phosphatases>Nek
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize NEK3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!