Rabbit polyclonal NELFE antibody (A7006)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NELFE antibody (A7006)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

RD antibody, RDP antibody, RDBP antibody, D6S45 antibody, NELF-E antibody
Major histocompatibility complex gene RD antibody|Negative elongation factor E antibody|Negative elongation factor polypeptide E antibody|NELF e antibody|NELF-E antibody|Nelfe antibody|NELFE_HUMAN antibody|Nuclear protein antibody|RD antibody|RD protein antibody|RD RNA binding protein antibody|RDP antibody|RNA-binding protein RD antibody|Anti-NELFe antibody [EPR11600] (ab170104)

SCBT cat No: sc-377052|sc-32912|

Name

Rabbit polyclonal NELFE antibody

Catalogue No.

A7006

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human NELFE

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 43kDa/Observed: Refer to figures

Formulation

NELFE antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NELFE antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RD antibody, RDP antibody, RDBP antibody, D6S45 antibody, NELF-E antibody

Database links

Human UniProt/Swiss-Prot:P18615

Protein names

RD, RDP, RDBP, D6S45, NELF-E

Protein function

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.

Protein tissue specificity

Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.

Protein sequence and domain

The RRM domain interacts with RNA, and is essential for NELF complex function. It is however not required for the NELF complex formation.Belongs to the RRM NELF-E family.; Contains 1 RRM (RNA recognition motif) domain.

Protein post-translational modifications

Sumoylated.

Protein cellular localization

Nucleus.

Background

The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.

Note

AntibodyPlus can customize NELFE antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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