Rabbit polyclonal NEU1 antibody (A6299)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NEU1 antibody (A6299)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

NEU antibody, NANH antibody, SIAL1 antibody
Acetylneuraminyl hydrolase antibody|exo-alpha-sialidase antibody|G9 sialidase antibody|Lysosomal sialidase antibody|N acetyl alpha neuraminidase 1 antibody|N-acetyl-alpha-neuraminidase 1 antibody|NANH antibody|NEU antibody|NEU1 antibody|NEUR1_HUMAN antibody|Neuraminidase 1 antibody|Neuraminidase antibody|SIAL1 antibody|sialidase 1 (lysosomal sialidase) antibody|Sialidase 1 antibody|Sialidase, lysosomal antibody|Sialidase-1 antibody|Anti-Neuraminidase antibody [3D4] (ab170166)

SCBT cat No: sc-166824|sc-32936|sc-25905|sc-25906|

Name

Rabbit polyclonal NEU1 antibody

Catalogue No.

A6299

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NEU1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to Figures

Formulation

NEU1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NEU1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NEU antibody, NANH antibody, SIAL1 antibody

Database links

Human UniProt/Swiss-Prot:Q99519

Protein names

NEU, NANH, SIAL1

Protein function

Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.

Protein tissue specificity

Highly expressed in pancreas, followed by skeletal muscle, kidney, placenta, heart, lung and liver. Weakly expressed in brain.

Protein sequence and domain

A C-terminal internalization signal (YGTL) appears to allow the targeting of plasma membrane proteins to endosomes.Belongs to the glycosyl hydrolase 33 family.; Contains 4 BNR repeats.

Protein post-translational modifications

N-glycosylated.; Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane.

Protein cellular localization

Lysosome membrane; Peripheral membrane protein; Lumenal side. Lysosome lumen. Cell membrane. Cytoplasmic vesicle. Note: Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.

Background

The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as ‘protective protein’). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.

Note

AntibodyPlus can customize NEU1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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