Rabbit polyclonal NFATC2 antibody (A3107)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NFATC2 antibody (A3107)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:1000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal NFATC2 antibody.

Alternative names:

Check alternative names for the antibody

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NFAT1 antibody, NFATP antibody
AI607462 antibody|cytoplasmic 2 antibody|KIAA0611 antibody|NF ATc2 antibody|NF ATp antibody|NF-ATc2 antibody|NF-ATp antibody|NFAC2_HUMAN antibody|NFAT 1 antibody|NFAT pre existing subunit antibody|NFAT pre-existing subunit antibody|NFAT transcription complex, preexisting component antibody|NFAT1 antibody|NFAT1-D antibody|NFATc2 antibody|NFATp antibody|Nuclear factor of activated T cells cytoplasmic 2 antibody|Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2 antibody|Nuclear factor of activated T cells pre-existing component antibody|Nuclear factor of activated T cells, preexisting component antibody|Nuclear factor of activated T-cells antibody|Preexisting nuclear factor of activated T cells 2 antibody|T cell transcription factor NFAT 1 antibody|T-cell transcription factor NFAT1 antibody|Anti-NFAT1 antibody [25A10.D6.D2] – ChIP Grade (ab2722)

SCBT cat No: sc-1151|

Name

Rabbit polyclonal NFATC2 antibody

Catalogue No.

A3107

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human NFATC2

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:1000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 98kDa/Observed: Refer to Figures

Formulation

NFATC2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NFATC2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NFAT1 antibody, NFATP antibody

Database links

Human UniProt/Swiss-Prot:Q13469

Protein names

NFAT1, NFATP

Protein function

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.

Protein tissue specificity

Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Isoform 1 is highly expressed in the small intestine, heart, testis, prostate, thymus, placenta and thyroid. Isoform 3 is highly expressed in stomach, uterus, placenta, trachea and thyroid.

Protein sequence and domain

the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.; Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.Contains 1 RHD (Rel-like) domain.

Protein post-translational modifications

In resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-363 region. Upon cell stimulation, all these sites except Ser-243 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change that simultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, Ser-53 or Ser-56 is phosphorylated; which is required for full transcriptional activity.; Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome.

Protein cellular localization

Cytoplasm. Nucleus. Note: Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

Background

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.

Research area

All research areas>Transcription Regulators>NFAT
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize NFATC2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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