Rabbit Polyclonal NFKBIZ antibody (A10492)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal NFKBIZ antibody (A10492)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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FLJ30225 antibody|FLJ34463 antibody|I-kappa-B-zeta antibody|Ikappa B zeta antibody|IkappaB zeta antibody|IkappaBzeta antibody|IkB-zeta antibody|IKBZ antibody|IKBZ_HUMAN antibody|IKBzeta antibody|IL-1 inducible nuclear ankyrin-repeat protein antibody|INAP antibody|MAIL antibody|MAIL protein antibody|Molecule possessing ankyrin repeats induced by lipopolysaccharide antibody|NF-kappa-B inhibitor zeta antibody|NFKBIZ antibody|Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor zeta antibody|Anti-IKB zeta antibody (ab168850)

SCBT cat No: sc-33421|sc-66935|sc-33419|

Name

Rabbit Polyclonal NFKBIZ antibody

Catalogue No.

A10492

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NFKBIZ

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

78kDa

Formulation

NFKBIZ antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Protein function

Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).

Protein tissue specificity

Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.

Protein sequence and domain

Contains 7 ANK repeats.

Protein cellular localization

Nucleus . Note=Aggregated in dot-like structures. Colocalizes with NCOR2.

Note

AntibodyPlus can customize NFKBIZ antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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