Rabbit polyclonal NGF antibody (A0258)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NGF antibody (A0258)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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NGF antibody,Beta-NGF antibody,HSAN5 antibody,MGC161426 antibody,MGC161428 antibody,NGFB antibody,proNGF antibody
Beta nerve growth factor antibody|Beta NGF antibody|Beta-nerve growth factor antibody|Beta-NGF antibody|HSAN5 antibody|MGC161426 antibody|MGC161428 antibody|Nerve growth factor (beta polypeptide) antibody|Nerve growth factor antibody|Nerve growth factor beta antibody|Nerve growth factor beta polypeptide antibody|Nerve growth factor beta subunit antibody|NGF antibody|NGF_HUMAN antibody|NGFB antibody|NID67 antibody|Anti-NGF antibody (ab6199)

SCBT cat No: sc-32300|

Name

Rabbit polyclonal NGF antibody

Catalogue No.

A0258

Reactivity

Human

Immunogen

Recombinant protein of human NGF

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 27kDa/Observed: Refer to Figures

Formulation

NGF antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NGF antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NGF antibody,Beta-NGF antibody,HSAN5 antibody,MGC161426 antibody,MGC161428 antibody,NGFB antibody,proNGF antibody

Database links

Human UniProt/Swiss-Prot:P01138

Protein names

NGF,Beta-NGF,HSAN5,MGC161426,MGC161428,NGFB,proNGF

Protein function

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI .

Protein sequence and domain

Belongs to the NGF-beta family.

Protein cellular localization

Secreted.

Background

Nerve growth factor (NGF) is a small, secreted protein and member of the neurotrophin family of growth factors that promote neuronal cell survival and differentiation (1). Producing cells release NGF that bind and activate TrkA high affinity receptors to mediate NGF-driven signaling. NGF also binds to a low affinity p75 (NTR) receptors, which belong to the death receptor family (2). Although NGF has been classically described as favoring neuron survival and differentiation, nerve growth factor can promote apoptosis in cells that contain p75 (NTR) and lack TrkA. NGF can induce neuron death in a variety of neurodegenerative conditions, including Alzheimer disease (3). Besides its neurotrophic actions, NGF has an effect on non-neuronal cells and may help mediate inflammation, angiogenesis, and stimulate breast cancer cell growth (4-6). NGF signaling is looking increasingly promising as potential drug targets for diseases.

Research area

All research areas>Neurobiology>NGF
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize NGF antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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