Rabbit polyclonal NGFR antibody (A2097)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NGFR antibody (A2097)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CD271 antibody, Gp80-LNGFR antibody, TNFRSF16 antibody, p75(NTR) antibody, p75NTR antibody
CD271 antibody|CD271 antigen antibody|Gp80 LNGFR antibody|Gp80-LNGFR antibody|Low affinity nerve growth factor receptor antibody|Low affinity neurotrophin receptor p75NTR antibody|Low-affinity nerve growth factor receptor antibody|Nerve growth factor receptor antibody|Nerve growth factor receptor TNFR superfamily member 16 antibody|NGF receptor antibody|Ngfr antibody|p75 ICD antibody|p75 Neurotrophin receptor antibody|p75 NTR antibody|p75(NTR) antibody|p75NTR antibody|TNFR Superfamily Member 16 antibody|TNFRSF16 antibody|TNR16_HUMAN antibody|Tumor necrosis factor receptor superfamily member 16 antibody|Anti-p75 NGF Receptor antibody (ab8874)

SCBT cat No: sc-71695|sc-71694|sc-71693|sc-271708|sc-6188|sc-25283|sc-8317|sc-55467|sc-5634|sc-13577|sc-6189|sc-58567|sc-56448|

Name

Rabbit polyclonal NGFR antibody

Catalogue No.

A2097

Reactivity

Human, Mouse

Immunogen

A synthetic peptide of human NGFR

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to Figures

Formulation

NGFR antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NGFR antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CD271 antibody, Gp80-LNGFR antibody, TNFRSF16 antibody, p75(NTR) antibody, p75NTR antibody

Database links

Human UniProt/Swiss-Prot:P08138

Protein names

CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR

Protein function

Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.

Protein sequence and domain

Death domain is responsible for interaction with RANBP9.; The extracellular domain is responsible for interaction with NTRK1.Contains 1 death domain.; Contains 4 TNFR-Cys repeats.

Protein post-translational modifications

N- and O-glycosylated.; O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.; Phosphorylated on serine residues.

Protein cellular localization

Membrane; Single-pass type I membrane protein.

Background

The p75 neurotrophin receptor (p75NTR), a member of the TNF receptor superfamily, is distinguished by multiple cysteine-rich ligand-binding domains, a single transmembrane sequence and a noncatalytic cytoplasmic domain (1). p75NTR displays paradoxical functions when acting alone or with other receptor proteins. Working in concert with Trk receptors, p75NTR recognizes neurotrophins and transmits trophic signals into the cell. Both p75NTR and TrkA are required to activate PI3K-Akt signaling, while TrkA can individually activate the MAP kinase pathway. In contrast, p75NTR, possibly through JNK, ensures appropriate apoptosis of injured neurons and improperly targeted neonatal neurons (2).The p75NTR protein undergoes sequential cleavage similar to APP and Notch. First, alpha-secretase removes the p75NTR ectodomain, eliminating ligand-mediated signaling. At this point, the membrane-tethered cleavage product can still fine-tune Trk-mediated trophic actions. gamma-secretase cleaves within the transmembrane domain to liberate the cytoplasmic tail from its membrane anchor and allow the p75NTR intracellular domain to translocate to the nucleus (3,4).

Research area

All research areas>Neurobiology>NGFR
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize NGFR antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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