Rabbit polyclonal NHLRC1 antibody (A6669)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NHLRC1 antibody (A6669)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal NHLRC1 antibody.

Alternative names:

Check alternative names for the antibody

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EPM2A antibody, EPM2B antibody, MALIN antibody, bA204B7.2 antibody
bA204B7.2 antibody|E3 ubiquitin-protein ligase NHLRC1 antibody|EPM2A antibody|EPM2B antibody|EPM2B gene antibody|Malin antibody|MGC119262 antibody|MGC119264 antibody|MGC119265 antibody|NHL repeat containing 1 antibody|NHL repeat containing E3 ubiquitin protein ligase 1 antibody|NHL repeat containing protein 1 antibody|NHL repeat-containing protein 1 antibody|NHL repeat-containing protein 1 gene antibody|NHLC1_HUMAN antibody|NHLRC 1 antibody|Nhlrc1 antibody|Anti-NHLRC1 antibody [S8518] (ab186261)

SCBT cat No: sc-293401|sc-67360|

Name

Rabbit polyclonal NHLRC1 antibody

Catalogue No.

A6669

Reactivity

Human

Immunogen

Recombinant protein of human NHLRC1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 42kDa/Observed: Refer to figures

Formulation

NHLRC1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NHLRC1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

EPM2A antibody, EPM2B antibody, MALIN antibody, bA204B7.2 antibody

Database links

Human UniProt/Swiss-Prot:Q6VVB1

Protein names

EPM2A, EPM2B, MALIN, bA204B7.2

Protein function

E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.

Protein tissue specificity

Expressed in brain, cerebellum, spinal cord, medulla, heart, liver, skeletal muscle and pancreas.

Protein sequence and domain

The RING domain is essential for ubiquitin E3 ligase activity.Contains 6 NHL repeats.; Contains 1 RING-type zinc finger.

Protein cellular localization

Endoplasmic reticulum. Nucleus. Note: Localizes at the endoplasmic reticulum and, to a lesser extent, in the nucleus.

Background

The protein encoded by this gene is a single subunit E3 ubiquitin ligase. Laforin is polyubiquitinated by the encoded protein. Defects in this intronless gene lead to an accumulation of laforin and onset of Lafora disease, also known as progressive myoclonic epilepsy type 2 (EPM2).

Note

AntibodyPlus can customize NHLRC1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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