Rabbit polyclonal NINL antibody (A7584)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NINL antibody (A7584)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal NINL antibody.

Alternative names:

Check alternative names for the antibody

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NLP antibody, dJ691N24.1 antibody
4930519N13Rik antibody|dJ691N24.1 antibody|Gm1004, antibody|Gm1634 antibody|mKIAA0980 antibody|Ninein like antibody|Ninein-like protein antibody|NINL antibody|NINL_HUMAN antibody|Nlp antibody|RGD1306152 antibody|RP23-193L22.3 antibody|RP4-691N24.1 antibody|Anti-NINL antibody (ab121110)

SCBT cat No: sc-85793|sc-85794|

Name

Rabbit polyclonal NINL antibody

Catalogue No.

A7584

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human NINL

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 156kDa/Observed: Refer to figures

Formulation

NINL antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NINL antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NLP antibody, dJ691N24.1 antibody

Database links

Human UniProt/Swiss-Prot:Q9Y2I6

Protein names

NLP, dJ691N24.1

Protein function

Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.

Protein tissue specificity

Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level). Expressed in fetal heart, skeletal muscle, liver, lung and cochlea, and in adult brain, testis, kidney and retina.

Protein sequence and domain

The KEN and D (destructive) boxes are required for the cell cycle-controlled NINL degradation by the APC/C pathway.Contains 4 EF-hand domains.

Protein post-translational modifications

Phosphorylated by PLK1 which disrupts its centrosome association and interaction with gamma-tubulin.; Ubiquitinated by the APC/C complex leading to its degradation.

Protein cellular localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm . Note: In interphase cells, NINL is transported to the centrosomes by the dynein-dynactin motor complex . During centrosome maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm .

Note

AntibodyPlus can customize NINL antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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