Rabbit polyclonal NME4 antibody (A8350)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal NME4 antibody (A8350)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal NME4 antibody.

Alternative names:

Check alternative names for the antibody

Expand

NDPK-D antibody, NM23H4 antibody, nm23-H4 antibody
metastatic inhibition factor NM23H4 antibody|mitochondrial antibody|NDK antibody|NDKM_HUMAN antibody|NDP kinase antibody|NDP kinase D antibody|NDP kinase, mitochondrial antibody|NDPK D antibody|NDPKD antibody|nm23 H4 antibody|nm23-H4 antibody|NM23D antibody|NM23H4 antibody|Nm23M4 antibody|NME/NM23 nucleoside diphosphate kinase 4 antibody|NME4 antibody|Non metastatic cells 4 protein expressed in antibody|Non metastatic protein 23, homolog 4 antibody|Nucleoside diphosphate kinase D antibody|Nucleoside diphosphate kinase, mitochondrial antibody|Nucleoside diphosphate kinase, mitochondrial antibody|Anti-NME4 antibody – C-terminal (ab71623)

SCBT cat No: sc-99071|

Name

Rabbit polyclonal NME4 antibody

Catalogue No.

A8350

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NME4

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 21kDa/Observed: Refer to figures

Formulation

NME4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NME4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NDPK-D antibody, NM23H4 antibody, nm23-H4 antibody

Database links

Human UniProt/Swiss-Prot:O00746

Protein names

NDPK-D, NM23H4, nm23-H4

Protein function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis . Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity . Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration . Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria . In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling .

Protein tissue specificity

Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes.

Protein sequence and domain

Belongs to the NDK family.

Protein cellular localization

Mitochondrion intermembrane space ; Peripheral membrane protein. Mitochondrion matrix . Note: Predominantly localized in the mitochondrion intermembrane space . Colocalizes with OPA1 in mitochondria .

Background

The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997

Research area

All research areas>Kinases and Phosphatases>nm23-H
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize NME4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!