Rabbit polyclonal NOD1 antibody (A1246)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NOD1 antibody (A1246)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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NOD1 antibody,CARD4 antibody,CLR7.1 antibody,NLRC1 antibody
CARD 4 antibody|CARD4 antibody|Caspase recruitment domain 4 antibody|Caspase recruitment domain containing protein 4 antibody|Caspase recruitment domain family member 4 antibody|Caspase recruitment domain protein 4 antibody|Caspase recruitment domain-containing protein 4 antibody|CLR 7.1 antibody|CLR7.1 antibody|NLR family CARD domain containing 1 antibody|NLRC 1 antibody|NLRC1 antibody|NOD 1 antibody|Nod1 antibody|NOD1 protein antibody|NOD1_HUMAN antibody|Nucleotide binding oligomerization domain containing 1 antibody|Nucleotide binding oligomerization domain leucine rich repeat and CARD domain containing 1 antibody|Nucleotide-binding oligomerization domain-containing protein 1 antibody|Protein Nod1 antibody|Anti-CARD4 antibody – C-terminal (ab170547)

SCBT cat No: sc-398696|sc-377111|sc-22045|sc-398398|sc-99163|

Name

Rabbit polyclonal NOD1 antibody

Catalogue No.

A1246

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NOD1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 108kDa/Observed: Refer to Figures

Formulation

NOD1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NOD1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NOD1 antibody,CARD4 antibody,CLR7.1 antibody,NLRC1 antibody

Database links

Human UniProt/Swiss-Prot:Q9Y239

Protein names

NOD1,CARD4,CLR7.1,NLRC1

Protein function

Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.

Protein tissue specificity

Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.

Protein sequence and domain

Contains 1 CARD domain.; Contains 9 LRR (leucine-rich) repeats.; Contains 1 NACHT domain.

Protein post-translational modifications

Ubiquitinated. ‘Lys-48’-linked polyubiquitination by RNF34 promotes proteasomal degradation and thereby negatively regulates NOD1 for instance in NF-kappa-B activition.

Protein cellular localization

Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Note: Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.

Background

Nod1/CARD4 is a cytosolic protein structually related to Apaf-1 and plant drug-resistance proteins that has been implicated in apoptosis and inflammatory responses to certain pathogenic bacteria (1-3). It contains an amino-terminal caspase recruitment domain (CARD) that is linked to a central nucleotide-binding domain (NBD; also known as a NOD domain) and is followed by carboxy-terminal leucine-rich repeats (LRR) (1). Like Apaf-1, Nod1 induces apoptosis by a CARD/NBD-dependent activation of caspase-9 (1). The primary function of Nod1 is thought to be as a sensor for certain pathogenic microbes and triggering inflammatory responses including the activation of NF-kappaB and JNK pathways (4-6). The LRR of Nod1 appears to be involved in recognition of microbial components and the CARD domain induces NF-kappaB activation in cooperation with the CARD containing kinase, RICK/RIP2/CARDIAK (1,5,6). Mutations in Nod1 have been linked increased susceptibility to asthma (7) and inflammatory bowel disease (8).

Research area

All research areas>Tumor Suppressor/Apoptosis>Nod
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize NOD1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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