Rabbit polyclonal NOS1 antibody (A1485)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NOS1 antibody (A1485)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IP 1:20 – 1:50

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

NOS1 antibody,IHPS1 antibody,N-NOS antibody,NC-NOS antibody,NOS antibody,Bnos antibody,nNOS antibody
2310005C01Rik antibody|BNOS antibody|Constitutive NOS antibody|EC 1.14.13.39 antibody|IHPS 1 antibody|IHPS1 antibody|N-NOS antibody|NC-NOS antibody|neuronal Nitric Oxide Synthase antibody|Neuronal NOS antibody|Nitric oxide synthase , neuronal, included antibody|Nitric oxide synthase 1 (neuronal) antibody|Nitric oxide synthase 1 antibody|Nitric oxide synthase, brain antibody|Nitric oxide synthase, penile neuronal, included antibody|NNOS antibody|NO antibody|NOS 1 antibody|NOS antibody|NOS type I antibody|NOS-I antibody|NOS1 antibody|NOS1_HUMAN antibody|Peptidyl-cysteine S-nitrosylase NOS1 antibody|Anti-nNOS (neuronal) antibody [EP1855Y] (ab76067)

SCBT cat No: sc-49058|sc-5302|sc-17825|sc-398843|sc-8309|sc-55521|sc-1025|sc-648|sc-7271|

Name

Rabbit polyclonal NOS1 antibody

Catalogue No.

A1485

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Protein of human NOS1

Host

Rabbit

Applications

WB, IHC, IP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IP 1:20 – 1:50

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 160kDa/Observed: Refer to Figures

Formulation

NOS1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NOS1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NOS1 antibody,IHPS1 antibody,N-NOS antibody,NC-NOS antibody,NOS antibody,Bnos antibody,nNOS antibody

Database links

Human UniProt/Swiss-Prot:P29475

Protein names

NOS1,IHPS1,N-NOS,NC-NOS,NOS,Bnos,nNOS

Protein function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.

Protein tissue specificity

Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.

Protein sequence and domain

The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles. Mediates interaction with VAC14 (By similarity).Belongs to the NOS family.; Contains 1 FAD-binding FR-type domain.; Contains 1 flavodoxin-like domain.; Contains 1 PDZ (DHR) domain.

Protein post-translational modifications

Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro).

Protein cellular localization

Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine . Note: In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).

Background

Nitric Oxide Synthase (NOS) catalyses the formation of nitric oxide (NO) and citruline from L-arginine, oxygen and cofactors. Three family members have been characterized: neuronal NOS (nNOS), which is found primarily in neuronal tissue; inducible NOS (iNOS), which is induced by interferon gamma and lipopolysaccharides in the kidney and cardiovascular system; and endothelial NOS (eNOS), which is expressed in blood vessels (1). NO is a messenger molecule with diverse functions throughout the body including the maintenance of vascular integrity, homeostasis, synaptic plasticity, long-term potentiation, learning, and memory (2,3).nNOS binds selectively to the second PDZ domain of PSD-95, and the enzymatic activity of nNOS is either downregulated by phosphorylation at Ser847 by CaM-KII or stimulated by calcium influxes governed by the NMDA receptor channels (4-5).

Research area

All research areas>Synthesis and Degradation>NOS
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize NOS1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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