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Rabbit polyclonal NOTCH2 antibody (A0560)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:100 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal NOTCH2 antibody.
Check alternative names for the antibodyExpand
hN2 antibody, AGS2 antibody, HJCYS antibody
AGS2 antibody|Aicardi-Goutieres syndrome 2 protein antibody|Deleted in lymphocytic leukemia 8 antibody|DLEU8 antibody|FLJ11712 antibody|Ribonuclease H2 subunit B antibody|Ribonuclease HI subunit B antibody|RNase H2 subunit B antibody|Rnaseh2b antibody|RNH2B_HUMAN antibody|Anti-Notch2 antibody (ab8926)
SCBT cat No: sc-7423|
Rabbit polyclonal NOTCH2 antibody
|Catalogue No.|| |
Recombinant protein of human NOTCH2
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 265kDa/Observed: Refer to figures
NOTCH2 antibody was tube-contained.
NOTCH2 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
hN2 antibody, AGS2 antibody, HJCYS antibody
|Database links|| |
|Protein names|| |
hN2, AGS2, HJCYS
|Protein function|| |
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells .
|Protein tissue specificity|| |
Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.
|Protein sequence and domain|| |
Belongs to the NOTCH family.; Contains 6 ANK repeats.; Contains 35 EGF-like domains.; Contains 3 LNR (Lin/Notch) repeats.
|Protein post-translational modifications|| |
Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity).; Hydroxylated by HIF1AN.; Can be either O-glucosylated or O-xylosylated at Ser-613 by POGLUT1.
|Protein cellular localization|| |
Notch 2 extracellular truncation: Cell membrane ; Single-pass type I membrane protein .; Notch 2 intracellular domain: Nucleus . Cytoplasm . Note: Following proteolytical processing NICD is translocated to the nucleus. Retained at the cytoplasm by C8orf4 .
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.
AntibodyPlus can customize NOTCH2 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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