Rabbit polyclonal NPRL2 antibody (A5859)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NPRL2 antibody (A5859)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal NPRL2 antibody.

Alternative names:

Check alternative names for the antibody

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NPR2 antibody, NPR2L antibody, TUSC4 antibody
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SCBT cat No: sc-376986|sc-166969|

Name

Rabbit polyclonal NPRL2 antibody

Catalogue No.

A5859

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NPRL2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 43kDa/Observed: Refer to Figures

Formulation

NPRL2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NPRL2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NPR2 antibody, NPR2L antibody, TUSC4 antibody

Database links

Human UniProt/Swiss-Prot:Q8WTW4

Protein names

NPR2, NPR2L, TUSC4

Protein function

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at ‘Tyr-9’, ‘Tyr-373’ and ‘Tyr-376’ residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.

Protein tissue specificity

Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.

Protein sequence and domain

Belongs to the NPR2 family.

Research area

All research areas>Tumor Suppressor/Apoptosis>NPRL
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize NPRL2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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