Rabbit polyclonal NR0B2 antibody (A1836)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NR0B2 antibody (A1836)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal NR0B2 antibody.

Alternative names:

Check alternative names for the antibody

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SHP antibody, SHP1 antibody
NR0B2 antibody|NR0B2_HUMAN antibody|Nr0b2a antibody|Nuclear receptor subfamily 0 group B member 2 antibody|Nuclear receptor subfamily 0, group B, member 2a antibody|Orphan nuclear receptor SHP antibody|SHP antibody|SHP-1 antibody|Shp1 antibody|Small heterodimer partner antibody|Anti-NR0B2 antibody (ab186874)

SCBT cat No:

Name

Rabbit polyclonal NR0B2 antibody

Catalogue No.

A1836

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NR0B2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 28kDa/Observed: Refer to Figures

Formulation

NR0B2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NR0B2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SHP antibody, SHP1 antibody

Database links

Human UniProt/Swiss-Prot:Q15466

Protein names

SHP, SHP1

Protein function

Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.

Protein tissue specificity

Liver. Low levels of expression were detected in heart and pancreas.

Protein sequence and domain

Belongs to the nuclear hormone receptor family. NR0 subfamily.

Protein post-translational modifications

Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.

Protein cellular localization

Nucleus . Cytoplasm . Note: Colocalizes with NEUROD1 in the nucleus.

Background

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

Note

AntibodyPlus can customize NR0B2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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