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Rabbit polyclonal NR0B2 antibody (A1836)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal NR0B2 antibody.
Check alternative names for the antibodyExpand
SHP antibody, SHP1 antibody
NR0B2 antibody|NR0B2_HUMAN antibody|Nr0b2a antibody|Nuclear receptor subfamily 0 group B member 2 antibody|Nuclear receptor subfamily 0, group B, member 2a antibody|Orphan nuclear receptor SHP antibody|SHP antibody|SHP-1 antibody|Shp1 antibody|Small heterodimer partner antibody|Anti-NR0B2 antibody (ab186874)
SCBT cat No:
Rabbit polyclonal NR0B2 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human NR0B2
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 28kDa/Observed: Refer to Figures
NR0B2 antibody was tube-contained.
NR0B2 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
SHP antibody, SHP1 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.
|Protein tissue specificity|| |
Liver. Low levels of expression were detected in heart and pancreas.
|Protein sequence and domain|| |
Belongs to the nuclear hormone receptor family. NR0 subfamily.
|Protein post-translational modifications|| |
Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.
|Protein cellular localization|| |
Nucleus . Cytoplasm . Note: Colocalizes with NEUROD1 in the nucleus.
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
AntibodyPlus can customize NR0B2 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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