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Rabbit polyclonal NR2C1 antibody (A6675)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal NR2C1 antibody.
Check alternative names for the antibodyExpand
NR2C 1 antibody|NR2C1 antibody|NR2C1_HUMAN antibody|NUCLEAR HORMONE RECEPTOR TR2 antibody|Nuclear receptor subfamily 2 group C member 1 antibody|Orphan nuclear receptor TR2 antibody|Testicular receptor 2 antibody|TR 2 antibody|TR2 antibody|Anti-TR2-11 antibody (ab83278)
SCBT cat No:
Rabbit polyclonal NR2C1 antibody
|Catalogue No.|| |
Recombinant protein of human NR2C1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 67kDa/Observed: Refer to figures
NR2C1 antibody was tube-contained.
NR2C1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5′-AGGTCA-3′ half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
|Protein sequence and domain|| |
Belongs to the nuclear hormone receptor family. NR2 subfamily.; Contains 1 nuclear receptor DNA-binding domain.
|Protein post-translational modifications|| |
Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity).; Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-222, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-581 by PKC is important for protein stability and function as activator of RARB (By similarity).
|Protein cellular localization|| |
Nucleus . Nucleus, PML body . Note: Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation.
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
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|Product type|| |
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