Rabbit polyclonal NRGN antibody (A8444)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NRGN antibody (A8444)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal NRGN antibody.

Alternative names:

Check alternative names for the antibody

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RC3 antibody, hng antibody
Protein kinase C substrate RC3 antibody|Calmodulin binding protein antibody|Hng antibody|NEUG(55-78) antibody|NEUG_HUMAN antibody|Neurogranin (protein kinase C substrate) antibody|Ng antibody|NRGN antibody|Protein kinase C substrate antibody|RC3 antibody|Anti-Neurogranin antibody (ab23570)

SCBT cat No: sc-515092|sc-18336|sc-50401|sc-514922|

Name

Rabbit polyclonal NRGN antibody

Catalogue No.

A8444

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NRGN

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 8kDa/Observed: Refer to figures

Formulation

NRGN antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NRGN antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RC3 antibody, hng antibody

Database links

Human UniProt/Swiss-Prot:Q92686

Protein names

RC3, hng

Protein function

Acts as a “third messenger” substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).

Protein tissue specificity

In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease.

Protein sequence and domain

Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical conformation.Belongs to the neurogranin family.; Contains 1 collagen-like domain.; Contains 1 IQ domain.

Protein post-translational modifications

Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions.

Background

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.

Note

AntibodyPlus can customize NRGN antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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