Rabbit polyclonal NTRK3 antibody (A5842)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NTRK3 antibody (A5842)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal NTRK3 antibody.

Alternative names:

Check alternative names for the antibody

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TRKC antibody, gp145(trkC) antibody
BDNF/NT-3 growth factors receptor antibody|Tyrosine kinase receptor A antibody|Tyrosine kinase receptor antibody|Anti-TrkA+B+C antibody [EPR17341] (ab181560)

SCBT cat No: sc-135645|sc-66159|sc-135790|sc-135789|sc-71947|sc-5839|sc-398471|

Name

Rabbit polyclonal NTRK3 antibody

Catalogue No.

A5842

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NTRK3

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 94kDa/Observed: Refer to Figures

Formulation

NTRK3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NTRK3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

TRKC antibody, gp145(trkC) antibody

Database links

Human UniProt/Swiss-Prot:Q16288

Protein names

TRKC, gp145(trkC)

Protein function

Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.

Protein tissue specificity

Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.; Contains 2 Ig-like C2-type (immunoglobulin-like) domains.; Contains 2 LRR (leucine-rich) repeats.; Contains 1 LRRCT domain.; Contains 1 protein kinase domain.

Protein post-translational modifications

Ligand-mediated auto-phosphorylation.

Protein cellular localization

Membrane; Single-pass type I membrane protein.

Background

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Neurobiology>Trk
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize NTRK3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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