Rabbit polyclonal NUDT1 antibody (A5474)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NUDT1 antibody (A5474)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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MTH1 antibody
2-hydroxy-dATP diphosphatase antibody|7 8 dihydro 8 oxoguanine triphosphatase antibody|7 antibody|8 oxo 7 8 dihydrodeoxyguanosine triphosphatase antibody|8 oxo 7 8 dihydroguanosine triphosphatase antibody|8 oxo dGTPase antibody|8-dihydro-8-oxoguanine triphosphatase antibody|8-oxo-dGTPase antibody|8ODP_HUMAN antibody|MTH 1 antibody|MTH1 antibody|MutT human homolog 1 antibody|Nucleoside diphosphate linked moiety X motif 1 antibody|Nucleoside diphosphate linked moiety X type motif 1 antibody|Nucleoside diphosphate-linked moiety X motif 1 antibody|Nudix (nucleoside diphosphate linked moiety X) type motif 1 antibody|Nudix hydrolase 1 antibody|Nudix motif 1 antibody|Nudix type motif 1 antibody|NUDT 1 antibody|Nudt1 antibody|Anti-MTH1 antibody [EPR15934-50] (ab200832)

SCBT cat No: sc-271082|sc-67291|

Name

Rabbit polyclonal NUDT1 antibody

Catalogue No.

A5474

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NUDT1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 22kDa/Observed: Refer to Figures

Formulation

NUDT1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NUDT1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MTH1 antibody

Database links

Human UniProt/Swiss-Prot:P36639

Protein names

MTH1

Protein function

Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Protein tissue specificity

Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.

Protein sequence and domain

Belongs to the Nudix hydrolase family.; Contains 1 nudix hydrolase domain.

Protein post-translational modifications

The N-terminus is blocked.

Protein cellular localization

Isoform p18: Cytoplasm. Mitochondrion matrix. Nucleus. Note: Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.; Isoform p26: Cytoplasm. Mitochondrion matrix.

Background

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Note

AntibodyPlus can customize NUDT1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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