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Rabbit polyclonal NUDT1 antibody (A5474)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal NUDT1 antibody.
Check alternative names for the antibodyExpand
2-hydroxy-dATP diphosphatase antibody|7 8 dihydro 8 oxoguanine triphosphatase antibody|7 antibody|8 oxo 7 8 dihydrodeoxyguanosine triphosphatase antibody|8 oxo 7 8 dihydroguanosine triphosphatase antibody|8 oxo dGTPase antibody|8-dihydro-8-oxoguanine triphosphatase antibody|8-oxo-dGTPase antibody|8ODP_HUMAN antibody|MTH 1 antibody|MTH1 antibody|MutT human homolog 1 antibody|Nucleoside diphosphate linked moiety X motif 1 antibody|Nucleoside diphosphate linked moiety X type motif 1 antibody|Nucleoside diphosphate-linked moiety X motif 1 antibody|Nudix (nucleoside diphosphate linked moiety X) type motif 1 antibody|Nudix hydrolase 1 antibody|Nudix motif 1 antibody|Nudix type motif 1 antibody|NUDT 1 antibody|Nudt1 antibody|Anti-MTH1 antibody [EPR15934-50] (ab200832)
SCBT cat No: sc-271082|sc-67291|
Rabbit polyclonal NUDT1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human NUDT1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 22kDa/Observed: Refer to Figures
NUDT1 antibody was tube-contained.
NUDT1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
|Protein tissue specificity|| |
Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
|Protein sequence and domain|| |
Belongs to the Nudix hydrolase family.; Contains 1 nudix hydrolase domain.
|Protein post-translational modifications|| |
The N-terminus is blocked.
|Protein cellular localization|| |
Isoform p18: Cytoplasm. Mitochondrion matrix. Nucleus. Note: Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.; Isoform p26: Cytoplasm. Mitochondrion matrix.
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
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|Product type|| |
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