Rabbit polyclonal NUMB antibody (A9352)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal NUMB antibody (A9352)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:20 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal NUMB antibody.

Alternative names:

Check alternative names for the antibody

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S171 antibody, C14orf41 antibody, c14_5527 antibody
c14_5527 antibody|C14orf41 antibody|FLJ31314 antibody|h Numb antibody|h-Numb antibody|Numb antibody|Numb homolog (Drosophila) antibody|Numb homolog antibody|Numb protein homolog antibody|NUMB_HUMAN antibody|Protein numb homolog antibody|Protein S171 antibody|S171 antibody|Anti-NUMB antibody (ab14140)

SCBT cat No: sc-136554|sc-25668|sc-15590|

Name

Rabbit polyclonal NUMB antibody

Catalogue No.

A9352

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human NUMB

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:20 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 71kDa/Observed: Refer to figures

Formulation

NUMB antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

NUMB antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

S171 antibody, C14orf41 antibody, c14_5527 antibody

Database links

Human UniProt/Swiss-Prot:P49757

Protein names

S171, C14orf41, c14_5527

Protein function

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

Protein sequence and domain

Contains 1 PID domain.

Protein post-translational modifications

Phosphorylated on Ser-276 and Ser-295 by CaMK1.; Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.

Protein cellular localization

Membrane; Peripheral membrane protein.

Background

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Neurobiology>NUMB
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize NUMB antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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