Rabbit polyclonal OLFM1 antibody (A0261)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal OLFM1 antibody (A0261)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal OLFM1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

OLFM1 antibody, NOELIN1 antibody, AMY antibody, olfactomedin 1 antibody, NOE1 antibody, Noelin antibody
AMY antibody|Noe1 antibody|NOE1_HUMAN antibody|Noel antibody|Noel1 antibody|Noelin antibody|Noelin1 antibody|OlfA antibody|Olfactomedin 1 antibody|Olfactomedin-1 antibody|Olfm1 antibody|Pancortin 1 antibody|Pancortin antibody|Anti-Noelin antibody – C-terminal (ab151416)

SCBT cat No: sc-165155|

Name

Rabbit polyclonal OLFM1 antibody

Catalogue No.

A0261

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Protein of human OLFM1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 55kDa/Observed: Refer to Figures

Formulation

OLFM1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

OLFM1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

OLFM1 antibody, NOELIN1 antibody, AMY antibody, olfactomedin 1 antibody, NOE1 antibody, Noelin antibody

Database links

Human UniProt/Swiss-Prot:Q99784

Protein names

OLFM1, NOELIN1, AMY, olfactomedin 1, NOE1, Noelin

Protein function

Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity).

Protein sequence and domain

The protein contains a globular N-terminal tetramerization domain, a long stalk formed by the coiled coil region and a C-terminal olfactomedin-like domain. Interactions between dimers are mediated by the coiled coil region. The dimers interact mostly via the N-terminal tetramerization domain, giving rise to a V-shaped overall architecture of the tetramer.Contains 1 olfactomedin-like domain.

Protein cellular localization

Secreted . Cell junction, synapse . Endoplasmic reticulum . Cell projection, axon . Perikaryon .

Background

The Olfactomedin family comprises a diverse group of secreted glycoproteins, which includes OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin and mycocilin. These proteins are implicated in the development of the nervous system. Specifically, OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse at E8-10, and later in brain tissue and in the zone of polarizing activity in the limb. Overexpression of OLFM1 causes an excess of neural crest emigrations and prolonged neural crest production. OLFM2 participates in the regulation of the development of the anterior nervous system. An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).

Research area

All research areas>Signaling Intermediates>OLFM
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize OLFM1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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