Rabbit polyclonal OPA1 antibody (A9833)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal OPA1 antibody (A9833)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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Dynamin like 120 kDa protein antibody|Dynamin like 120 kDa protein, mitochondrial antibody|Dynamin-like 120 kDa protein, form S1 antibody|FLJ12460 antibody|Juvenile kjer type optic atrophy antibody|KIAA0567 antibody|KJER type antibody|Large GTP binding protein antibody|largeG antibody|MGM1 antibody|Mitochondrial dynamin like 120 kDa protein antibody|Mitochondrial dynamin like GTPase antibody|NPG antibody|NTG antibody|OAK antibody|OPA 1 antibody|opa1 antibody|OPA1 gene antibody|OPA1_HUMAN antibody|Optic atrophy 1 (autosomal dominant) antibody|OPTIC ATROPHY 1 antibody|Optic atrophy 1 gene protein antibody|Optic atrophy 1 homolog (human) antibody|Optic atrophy protein 1 antibody|Optic atrophy protein 1 homolog antibody|Anti-OPA1 antibody (ab42364)

SCBT cat No: sc-30573|sc-367890|sc-30572|

Name

Rabbit polyclonal OPA1 antibody

Catalogue No.

A9833

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human OPA1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 112kDa/Observed: Refer to figures

Formulation

OPA1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

OPA1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:O60313

Protein function

Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. May also play a role in mitochondrial genome maintenance.; Dynamin-like 120 kDa protein, form S1: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.

Protein tissue specificity

Highly expressed in retina. Also expressed in brain, testis, heart and skeletal muscle. Isoform 1 expressed in retina, skeletal muscle, heart, lung, ovary, colon, thyroid gland, leukocytes and fetal brain. Isoform 2 expressed in colon, liver, kidney, thyroid gland and leukocytes. Low levels of all isoforms expressed in a variety of tissues.

Protein sequence and domain

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.; Contains 1 dynamin-type G (guanine nucleotide-binding) domain.

Protein post-translational modifications

PARL-dependent proteolytic processing releases an antiapoptotic soluble form not required for mitochondrial fusion. Cleaved by OMA1 at position S1 following stress conditions.

Protein cellular localization

Mitochondrion inner membrane ; Single-pass membrane protein . Mitochondrion intermembrane space .

Background

This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Note

AntibodyPlus can customize OPA1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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