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Rabbit polyclonal OPA1 antibody (A9833)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
Dynamin like 120 kDa protein antibody|Dynamin like 120 kDa protein, mitochondrial antibody|Dynamin-like 120 kDa protein, form S1 antibody|FLJ12460 antibody|Juvenile kjer type optic atrophy antibody|KIAA0567 antibody|KJER type antibody|Large GTP binding protein antibody|largeG antibody|MGM1 antibody|Mitochondrial dynamin like 120 kDa protein antibody|Mitochondrial dynamin like GTPase antibody|NPG antibody|NTG antibody|OAK antibody|OPA 1 antibody|opa1 antibody|OPA1 gene antibody|OPA1_HUMAN antibody|Optic atrophy 1 (autosomal dominant) antibody|OPTIC ATROPHY 1 antibody|Optic atrophy 1 gene protein antibody|Optic atrophy 1 homolog (human) antibody|Optic atrophy protein 1 antibody|Optic atrophy protein 1 homolog antibody|Anti-OPA1 antibody (ab42364)
SCBT cat No: sc-30573|sc-367890|sc-30572|
Rabbit polyclonal OPA1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human OPA1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 112kDa/Observed: Refer to figures
OPA1 antibody was tube-contained.
OPA1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. May also play a role in mitochondrial genome maintenance.; Dynamin-like 120 kDa protein, form S1: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.
|Protein tissue specificity|| |
Highly expressed in retina. Also expressed in brain, testis, heart and skeletal muscle. Isoform 1 expressed in retina, skeletal muscle, heart, lung, ovary, colon, thyroid gland, leukocytes and fetal brain. Isoform 2 expressed in colon, liver, kidney, thyroid gland and leukocytes. Low levels of all isoforms expressed in a variety of tissues.
|Protein sequence and domain|| |
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.; Contains 1 dynamin-type G (guanine nucleotide-binding) domain.
|Protein post-translational modifications|| |
PARL-dependent proteolytic processing releases an antiapoptotic soluble form not required for mitochondrial fusion. Cleaved by OMA1 at position S1 following stress conditions.
|Protein cellular localization|| |
Mitochondrion inner membrane ; Single-pass membrane protein . Mitochondrion intermembrane space .
This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
AntibodyPlus can customize OPA1 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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