Rabbit polyclonal OPRL1 antibody (A3113)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal OPRL1 antibody (A3113)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal OPRL1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

OOR antibody, ORL1 antibody, KOR-3 antibody, NOCIR antibody
H.sapiens mRNA for ORL1 receptor antibody|KOR 3 antibody|KOR-3 antibody|KOR3 antibody|LC132 receptor like antibody|LC132 receptor, rat, homolog of antibody|MGC34578 antibody|Nociceptin receptor antibody|Nociceptin/orphanin FQ (N/OFQ) peptide receptor antibody|NOCIR antibody|NOP antibody|OOR antibody|Opiate receptor like 1 antibody|Opiod receptor like 1 antibody|Oprl1 antibody|OPRX_HUMAN antibody|ORL1 antibody|Orphanin FQ receptor antibody|Anti-Nociceptin receptor antibody (ab66219)

SCBT cat No: sc-9760|sc-15309|sc-9759|

Name

Rabbit polyclonal OPRL1 antibody

Catalogue No.

A3113

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human OPRL1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 41kDa/Observed: Refer to Figures

Formulation

OPRL1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

OPRL1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

OOR antibody, ORL1 antibody, KOR-3 antibody, NOCIR antibody

Database links

Human UniProt/Swiss-Prot:P41146

Protein names

OOR, ORL1, KOR-3, NOCIR

Protein function

G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.

Protein tissue specificity

Detected in blood leukocytes.

Protein sequence and domain

Belongs to the G-protein coupled receptor 1 family.

Protein post-translational modifications

Phosphorylation at Ser-363 requires ADRBK2.

Protein cellular localization

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note: Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.

Background

The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Three transcript variants encoding the same protein have been found for this gene.

Research area

All research areas>Neurobiology>KOR
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize OPRL1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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