Rabbit Polyclonal P2RX7 antibody (A10511)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal P2RX7 antibody (A10511)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:1000 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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P2X7 antibody;
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SCBT cat No:

Name

Rabbit Polyclonal P2RX7 antibody

Catalogue No.

A10511

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human P2RX7

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

69kDa

Formulation

P2RX7 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

P2X7 antibody;

Protein names

P2X7;

Protein function

Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.

Protein tissue specificity

Widely expressed with highest levels in brain and immune tissues.

Protein sequence and domain

Belongs to the P2X receptor family.

Protein post-translational modifications

Phosphorylation results in its inactivation.; ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel.; Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface.

Protein cellular localization

Cell membrane ; Multi-pass membrane protein.

Background

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.

Note

AntibodyPlus can customize P2RX7 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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