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Rabbit Polyclonal P2RX7 antibody (A10511)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:1000 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal P2RX7 antibody.
Check alternative names for the antibodyExpand
SCBT cat No:
Rabbit Polyclonal P2RX7 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human P2RX7
|Recommended dilution|| |
WB 1:1000 – 1:2000
|Molecular weight|| |
P2RX7 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/Q99572">Q99572</a>
|Protein names|| |
|Protein function|| |
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
|Protein tissue specificity|| |
Widely expressed with highest levels in brain and immune tissues.
|Protein sequence and domain|| |
Belongs to the P2X receptor family.
|Protein post-translational modifications|| |
Phosphorylation results in its inactivation.; ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel.; Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface.
|Protein cellular localization|| |
Cell membrane ; Multi-pass membrane protein.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
AntibodyPlus can customize P2RX7 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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