Rabbit polyclonal PA2G4 antibody (A5376)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP,RIP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PA2G4 antibody (A5376)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP,RIP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:20 – 1:50 RIP 1:20 – 1:50

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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EBP1 antibody, HG4-1 antibody, p38-2G4 antibody
38kDa antibody|AA672939 antibody|Cell cycle protein p38 2G4 homolog antibody|Cell cycle protein p38-2G4 homolog antibody|ErbB-3 binding protein 1 antibody|ErbB3 binding protein 1 antibody|ErbB3-binding protein 1 antibody|ErbB3-binding protein Ebp1 antibody|hG4 1 antibody|hG4-1 antibody|IRES-specific cellular trans-acting factor 45 kDa antibody|MGC81621 antibody|MGC94070 antibody|Mpp1 antibody|p38 2G4 antibody|Pa2g4 antibody|PA2G4_HUMAN antibody|Plfap antibody|Proliferation associated 2G4 antibody|Proliferation associated 2G4, 38-KD antibody|Proliferation-associated 2G4, 38kDa antibody|Proliferation-associated 2G4, a antibody|Proliferation-associated protein 1 antibody|Proliferation-associated protein 2G4 antibody|Protein p38-2G4 antibody|si:dz150i12.2 antibody|wu:fb19b11 antibody|wu:ft56d05 antibody|zgc:86732 antibody|Anti-EBP1 antibody (ab33613)

SCBT cat No: sc-393114|sc-292466|sc-68477|sc-133531|

Name

Rabbit polyclonal PA2G4 antibody

Catalogue No.

A5376

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PA2G4

Host

Rabbit

Applications

WB, IHC, IF, IP, RIP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200
IP 1:20 – 1:50
RIP 1:20 – 1:50

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 43kDa/Observed: Refer to Figures

Formulation

PA2G4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PA2G4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

EBP1 antibody, HG4-1 antibody, p38-2G4 antibody

Database links

Human UniProt/Swiss-Prot:Q9UQ80

Protein names

EBP1, HG4-1, p38-2G4

Protein function

May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).

Protein tissue specificity

Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver.

Protein sequence and domain

Belongs to the peptidase M24 family.

Protein post-translational modifications

Phosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization.; In cancer cells, isoform 2 is polyubiquitinated leading to its proteasomal degradation and phosphorylation by PKC/PRKCD enhances polyubiquitination.

Protein cellular localization

Isoform 1: Cytoplasm . Nucleus, nucleolus . Note: Tranlocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization.; Isoform 2: Cytoplasm .

Background

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.

Note

AntibodyPlus can customize PA2G4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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