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Rabbit polyclonal PA2G4 antibody (A5376)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF,IP,RIP
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:20 – 1:50 RIP 1:20 – 1:50
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal PA2G4 antibody.
Check alternative names for the antibodyExpand
EBP1 antibody, HG4-1 antibody, p38-2G4 antibody
38kDa antibody|AA672939 antibody|Cell cycle protein p38 2G4 homolog antibody|Cell cycle protein p38-2G4 homolog antibody|ErbB-3 binding protein 1 antibody|ErbB3 binding protein 1 antibody|ErbB3-binding protein 1 antibody|ErbB3-binding protein Ebp1 antibody|hG4 1 antibody|hG4-1 antibody|IRES-specific cellular trans-acting factor 45 kDa antibody|MGC81621 antibody|MGC94070 antibody|Mpp1 antibody|p38 2G4 antibody|Pa2g4 antibody|PA2G4_HUMAN antibody|Plfap antibody|Proliferation associated 2G4 antibody|Proliferation associated 2G4, 38-KD antibody|Proliferation-associated 2G4, 38kDa antibody|Proliferation-associated 2G4, a antibody|Proliferation-associated protein 1 antibody|Proliferation-associated protein 2G4 antibody|Protein p38-2G4 antibody|si:dz150i12.2 antibody|wu:fb19b11 antibody|wu:ft56d05 antibody|zgc:86732 antibody|Anti-EBP1 antibody (ab33613)
SCBT cat No: sc-393114|sc-292466|sc-68477|sc-133531|
Rabbit polyclonal PA2G4 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human PA2G4
WB, IHC, IF, IP, RIP
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 43kDa/Observed: Refer to Figures
PA2G4 antibody was tube-contained.
PA2G4 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
EBP1 antibody, HG4-1 antibody, p38-2G4 antibody
|Database links|| |
|Protein names|| |
EBP1, HG4-1, p38-2G4
|Protein function|| |
May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).
|Protein tissue specificity|| |
Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver.
|Protein sequence and domain|| |
Belongs to the peptidase M24 family.
|Protein post-translational modifications|| |
Phosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization.; In cancer cells, isoform 2 is polyubiquitinated leading to its proteasomal degradation and phosphorylation by PKC/PRKCD enhances polyubiquitination.
|Protein cellular localization|| |
Isoform 1: Cytoplasm . Nucleus, nucleolus . Note: Tranlocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization.; Isoform 2: Cytoplasm .
This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.
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|Product type|| |
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